848827-35-0

Basic information

• Product Name: C₃₁H₃₆O₄
• Synonyms: C₃₁H₃₆O₄
• CAS NO: 848827-35-0
• Molecular Weight: 472.624
• Mol File: 848827-35-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₆O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₆O₄(848827-35-0)
• EPA Substance Registry System: C₃₁H₃₆O₄(848827-35-0)

Safety Data

• Hazardous Substances Data: 848827-35-0(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 54503-64-9 2,3-O-isopropylidene-5-O-trityl-D-ribofuranose 
• 22949-84-4 butyl(triphenyl)phosphonium iodide 

Relevant articles and documents

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation

Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with truncated sphingosine chains for biological evaluation, with particular emphasis on the Th1/Th2 distribution. Starting from a common precursor, d-lyxose, the sphingosine derivatives were synthesised via a straightforward Wittig condensation.