849353-44-2

Basic information

• Product Name: Benzonitrile, 4-hydroxy-3-methyl-5-nitro-
• CAS NO: 849353-44-2
• Molecular Formula: C8H6N2O3
• Molecular Weight: 178.147
• Mol File: 849353-44-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-hydroxy-3-methyl-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-hydroxy-3-methyl-5-nitro-(849353-44-2)
• EPA Substance Registry System: Benzonitrile, 4-hydroxy-3-methyl-5-nitro-(849353-44-2)

Safety Data

• Hazardous Substances Data: 849353-44-2(Hazardous Substances Data)

Upstream product

• 854627-73-9 4-bromo-3-methyl-5-nitrobenzonitrile 
• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 6933-10-4 amino-5-bromo-2-toluene 
• 15777-70-5 4-hydroxy-3-methylbenzonitrile 
• 13061-96-6 dihydroxy-methyl-borane 
• 1689-89-0 nitroxynil 

Downstream Products

• 850335-09-0 methyl 4-hydroxy-3-methyl-5-nitrobenzoate 
• 1093397-19-3 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide 
• 1292821-35-2 C₃₀H₂₇F₃N₄O₂ 
• 1093565-24-2 C₁₆H₁₀N₂O₃ 
• 1292821-26-1 C₂₇H₂₁F₃N₄O₂ 
• 942215-54-5 3-amino-4-hydroxy-5-methylbenzonitrile 
• 1093397-18-2 methyl 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)benzoate 
• 1093397-20-6 lithium 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)benzoate 

Relevant articles and documents

2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole 11v, which raised HDLc by 24 mg/dl in our transgenic mouse PD model.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.