84964-24-9

Basic information

• Product Name: 1-(3-BROMOPHENYL)PIPERIDINE
• Synonyms: N-(3-BROMOPHENYL)PIPERIDINE;1-(3-BROMOPHENYL)PIPERIDINE;1-Piperidino-3-bromobenzene
• CAS NO: 84964-24-9
• Molecular Formula: C₁₁H₁₄BrN
• Molecular Weight: 240.14
• Mol File: 84964-24-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 322.7°C at 760 mmHg
• Flash Point: 148.9°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 0.000275mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Room temperature.
• PKA: 5.68±0.20(Predicted)
• CAS DataBase Reference: 1-(3-BROMOPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOPHENYL)PIPERIDINE(84964-24-9)
• EPA Substance Registry System: 1-(3-BROMOPHENYL)PIPERIDINE(84964-24-9)

Safety Data

• Hazardous Substances Data: 84964-24-9(Hazardous Substances Data)

Usage

General Description

1-(3-Bromophenyl)piperidine is a chemical compound that features prominently in organic chemistry. As the name suggests, it contains a bromophenyl group (a benzene ring with a bromine atom substituted in) attached to a piperidine ring, forming a complex, cyclic structure. It's used as an intermediate in the synthesis of various pharmaceuticals and other organic compounds. The bromophenyl group makes it highly reactive, as the bromine atom can easily be replaced by other groups in a reaction, allowing for a wide range of potential derivatives. Handling and storage of this chemical must be done with care, due to its reactivity and potential health hazards. As with many brominated compounds, it's likely to be hazardous to the environment.

InChI:InChI=1/C11H14BrN/c12-10-5-4-6-11(9-10)13-7-2-1-3-8-13/h4-6,9H,1-3,7-8H2

Upstream product

• 110-89-4 piperidine 
• 108-36-1 1,3-dibromobenzene 
• 111-24-0 1,5-dibromo-pentane 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 38348-83-3 1-(3-bromophenyl)-2-pyrrolidinone 
• 852227-97-5 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine 
• 1432450-88-8 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(3-(piperidin-1-yl)phenyl)quinazolin-4-amine 
• 84964-31-8 11-Phenyl-3-piperidino-6,11-dihydrodibenzothiepin-11-ol 
• 84964-34-1 11-phenyl-3-piperidino-6,11-dihydrodibenzothiepin 

Relevant articles and documents

Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction

Anilines are key constituents in biologically active compounds and often obtained from transition metal-catalyzed coupling of an aryl halide with an amine. In this work, we report a transition metal-free method for the synthesis of meta-bromo- and meta-trifluoromethylanilines starting from 3-tribromomethylcyclopentanone or 3-(2-bromo-2-chloro-1,1,1-trifluoroethyl)cyclopentanone, respectively. The scope of the transformation is shown by application of primary, secondary and aromatic amines. The reaction proceeds in acceptable to high yields (20–81 %), and allows for the synthesis of anilines with substitution patterns otherwise difficult to access.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Selective functionalization of sp3 C - H bonds adjacent to nitrogen using (diacetoxyiodo)benzene (DIB)

(Chemical Equation Presented) A PhI(OAc)2 mediated selective functionalization of sp3C - H bonds adjacent to a nitrogen atom has been reported. When piperidine derivates were used, direct diacetoxylation of α and β sp3 C - H adjacent to a nitrogen atom were observed to afford various cis-2,3-diacetoxylated piperidines. On the other hand, tetrahydroisoquinoline derivatives gave various α-C - H functionalized products in the presence of PhI(OAc)2. Nitroalkanes, dialkyl malonates, and β-keto ester are active participants in this coupling reaction. Meanwhile, α-amino nitriles can also be obtained by oxidative coupling of amineswithmalononitrile. 2009 American Chemical Society.