850348-88-8Relevant articles and documents
Chemical biology of genomic DNA: Minimizing PCR bias
McInroy, Gordon R.,Raiber, Eun-Ang,Balasubramanian, Shankar
, p. 12047 - 12049 (2014)
The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde-reactive biotinylation probe. This journal is
NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
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Paragraph 0786, (2020/07/26)
Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.