850568-25-1

Basic information

• Product Name: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID
• Synonyms: 4-(PYRIDIN-2-YL-AMINOCARBONYL)BENZENEBORONIC ACID;4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID;N-2-PYRIDINYL 4-BORONOBENZAMIDE;4-(Pyridin-2-yl-aminocarbonyl)benzeneboronic acid 97%;4-(2-PyridylcarbaMoyl)benzeneboronic acid, 97%;(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic acid;4-(Pyridin-2-yl-aminocarbonyl)benzeneboronicacid97%;EOS-61700
• CAS NO: 850568-25-1
• Molecular Formula: C12H11BN2O3
• Molecular Weight: 242.04
• Product Categories: blocks;BoronicAcids
• Mol File: 850568-25-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 124-128
• Appearance: /
• Density: 1.33 g/cm³
• Refractive Index: 1.627
• Storage Temp.: Keep Cold
• PKA: 8.10±0.16(Predicted)
• CAS DataBase Reference: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(850568-25-1)
• EPA Substance Registry System: 4-(PYRIDIN-2-YL)AMINOCARBONYLPHENYLBORONIC ACID(850568-25-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 850568-25-1(Hazardous Substances Data)

Usage

Physical Form

Solid

Uses

4-(Pyridin-2-yl)aminocarbonylphenylboronic acid is a useful research chemical.

InChI:InChI=1/C12H11BN2O3/c16-12(15-11-3-1-2-8-14-11)9-4-6-10(7-5-9)13(17)18/h1-8,17-18H,(H,14,15,16)

Upstream product

• 5419-55-6 Triisopropyl borate 
• 300401-95-0 4-iodo-N-(pyridin-2-yl)benzamide 
• 14547-83-2 4-bromo-N-(pyridin-2-yl)benzamide 
• 504-29-0 2-aminopyridine 
• 586-76-5 4-Bromobenzoic acid 
• 14047-29-1 4-carboxyphenylboronic acid 

Relevant articles and documents

FURO[3,4-B]PYRROLE-CONTAINING BTK INHIBITOR

The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.

PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-A]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE

The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Bruton's tyrosine kinase inhibitor

The invention relates to a compound with a formula I and a pharmaceutically acceptable salt, a solvent compound, an active metabolite, a polycrystalline compound, an ester, an isomer or a prodrug thereof, a pharmaceutical composition containing the compound in the formula I, and application using the same as a selective Bruton's tyrosine kinase inhibitor to prepare a medicine for preventing or treating heterologous immunity diseases and self immunity diseases or cancers. The formula is shown in the specification.