850623-45-9

Basic information

• Product Name: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE
• Synonyms: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE;PotassiuM 4-(benzyloxycarbonylaMino)phenyltrifluoroborate, 96%;potassiuM (4-{[(benzyloxy)carbonyl]aMino}phenyl)trifluoroboranuide;Borate(1-),trifluoro[4-[[(phenylMethoxy)carbonyl]aMino]phenyl]-, potassiuM (1:1), (T-4)-
• CAS NO: 850623-45-9
• Molecular Formula: C₁₄H₁₂BF₃NO₂*K
• Molecular Weight: 333.16
• Product Categories: blocks;Trifluoroborates
• Mol File: 850623-45-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 250-266℃
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE(CAS DataBase Reference)
• NIST Chemistry Reference: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE(850623-45-9)
• EPA Substance Registry System: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE(850623-45-9)

Safety Data

• Hazardous Substances Data: 850623-45-9(Hazardous Substances Data)

Usage

General Description

POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is a chemical compound containing potassium and a trifluoroborate moiety attached to a 4-CBZ-aminophenyl group. It is commonly used in organic synthesis as a versatile reagent for the preparation of a wide range of organic compounds. It is known for its stability and high reactivity, making it a valuable tool for the development of new pharmaceuticals, agrochemicals, and materials. Additionally, it is used in the production of various functional polymers, as well as in the manufacture of specialty chemicals and fine chemicals. Overall, POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE is a crucial component in the field of organic chemistry and plays a significant role in the advancement of various industries.

Downstream Products

• 1017601-67-0 C₂₆H₂₄N₂O₃ 
• 1226980-82-0 C₂₀H₁₉NO₃ 
• 1207290-79-6 benzyl 4-(2,2,6-trimethyl-4-oxo-4H-1,3-dioxin-5-yl)phenylcarbamate 

Relevant articles and documents

Functionalization of (2S)-Isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4- ones by a Suzuki-Miyaura Cross-Coupling Reaction Using Aryltrifluoroborate Salts: Convenient Enantioselective Preparation of α-Substituted β-Amino Acids

A simple protocol for the Pd(OAc)2-catalyzed cross-coupling reaction of 1-benzoyl-(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-ones with potassium aryltrifluoroborates was developed. The reaction is performed at 110°C with a ligand-free catalyst. In all cases, complete conversion of the 1-benzoyl-(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-onesand aryltrifluoroborates into the C-C coupling products was observed within 30-360 min. It is noteworthy that a largevariety of groups present in the potassium aryltrifluoroborates (-CF3, -OMe, -SEt, -CN, -CHO, -Cl, -Cbz, -NCbz,-OH, -CO2H) could be tolerated. Hydrogenation of the endocyclic double bonds in the Suzuki-Miyaura products followed by acid hydrolysis afforded highly enantioenrichedα-aryl-substituted β-amino acids. We present a general approach for the synthesis of (2S)-isopropyl-5-aryl-2,3- dihydro-4(H)-pyrimidin-4-ones by Suzuki-Miyaura reaction of aryltrifluoroborate salts with(2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-ones in the presence of a palladium catalyst and a base. The arylated compounds were transformed into enantioenriched α-aryl-substituted β-amino acids. Copyright