85090-26-2

Basic information

• Product Name: 5-methyl-2-phenylisoindoline-1,3-dione
• Synonyms: 5-methyl-2-phenylisoindoline-1,3-dione
• CAS NO: 85090-26-2
• Molecular Weight: 237.258
• Mol File: 85090-26-2.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-phenylisoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-phenylisoindoline-1,3-dione(85090-26-2)
• EPA Substance Registry System: 5-methyl-2-phenylisoindoline-1,3-dione(85090-26-2)

Safety Data

• Hazardous Substances Data: 85090-26-2(Hazardous Substances Data)

Upstream product

• 40314-06-5 5-methyl-1H-isoindole-1,3-(2H)-dione 
• 71-43-2 benzene 
• 941-69-5 N-phenyl-maleimide 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 1197040-29-1 phenyl isocyanate 
• 52548-14-8 2-iodoyl-5-methylbenzoic acid 
• 4727-29-1 phthalanilic acid 
• 119072-55-8 tert-butylisonitrile 
• 42872-73-1 4-methyl-2-bromobenzonitrile 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 
• 164918-75-6 (3-methylphenyl)(1-pyrrolidinyl)methanone 
• 59746-40-6 pyrrolidin-1-yl(p-tolyl)methanone 
• 24623-20-9 2,3-dihydro-6-methyl-1H-inden-1-one 

Downstream Products

• 6833-18-7 4-methyl-N-phenylbenzamide 
• 23099-05-0 3-methyl-N-phenylbenzamide 
• 33886-51-0 6-methyl-2-phenylisoindolin-1-one 
• 134553-14-3 4-(6-diethylaminobenzofuranyl)-N-phenylphthalimide 
• 134508-26-2 4-bromomethyl-N-phenylphthalimide 
• 84839-34-9 5-methyl-anti-7,8-diazabicyclo<2.2.2>oct-5-ene-2,3,7,8-tetracarboxylic acid bis-N-phenylimide 
• 84839-34-9 5-methyl-syn-7,8-diazabicyclo<2.2.2>oct-5-ene-2,3,7,8-tetracarboxylic acid bis-N-phenylimide 

Relevant articles and documents

COMPOUNDS

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Organocatalyzed Synthesis of Highly Functionalized Phthalimides via Diels-Alder Reaction Employing Two Dienophiles

An efficient and facile protocol for the synthesis of biologically and pharmaceutically important phthalimides is developed by l-proline-catalyzed reaction between two dienophiles of α,β-unsaturated aldehydes and maleimides. The reaction involves an efficient benzannulation that proceeds via a formal [4 + 2] cycloaddition of azadiene intermediates generated in situ from enals and N-substituted maleimides. This protocol provides a variety of functionalized phthalimide derivatives, including a potent COX-2 enzyme inhibitor.

Ru-Catalyzed Selective C-H Bond Hydroxylation of Cyclic Imides

We report on cyclic imides as weak directing groups for selective monohydroxylation reactions using ruthenium catalysis. Whereas acyclic amides are known to promote the hydroxylation of the C(sp2)-H bond enabling five-membered ring ruthenacycle intermediates, the cyclic imides studied herein enabled the hydroxylation of the C(sp2)-H bond via larger six-membered ruthenacycle intermediates. Furthermore, monohydroxylated products were exclusively obtained (even in the presence of overstoichiometric amounts of reagents), which was rationalized by the difficulty to accommodate coplanar intermediates once the first hydroxyl group was introduced into the substrate. The same reactivity was observed in the presence of palladium catalysts.