851193-71-0 Usage
Chemical class
pyrrole derivatives
Potency
potent and selective
Receptor
free fatty acid receptor 1 (FFAR1) agonist
Therapeutic applications
metabolic diseases (e.g. type 2 diabetes, dyslipidemia)
Effects
improves glucose tolerance, increases insulin sensitivity, reduces hepatic glucose production
Preclinical models
studied in
Ethyl ester form
increased stability, suitable for pharmaceutical development
Potential
promising drug candidate for metabolic disorders
Check Digit Verification of cas no
The CAS Registry Mumber 851193-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,9 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 851193-71:
(8*8)+(7*5)+(6*1)+(5*1)+(4*9)+(3*3)+(2*7)+(1*1)=170
170 % 10 = 0
So 851193-71-0 is a valid CAS Registry Number.
851193-71-0Relevant articles and documents
A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346
Zarrinmayeh, Hamideh,Tromiczak, Eric,Zimmerman, Dennis M.,Rankl, Nancy,Ho, Ken H.,Dominguez, Esteban,Castano, Ana,Escribano, Ana,Fernandez, Carmen,Jimenez, Alma,Hornback, William J.,Nisenbaum, Eric S.
, p. 5203 - 5206 (2011/11/14)
The synthesis and structure-activity relationship (SAR) of novel and highly potent positive allosteric modulators of AMPA receptors, 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, are described. These studies indicated that higher
