851651-86-0

Basic information

• Product Name: N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide
• Synonyms: N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide
• CAS NO: 851651-86-0
• Molecular Weight: 263.296
• Mol File: 851651-86-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide(851651-86-0)
• EPA Substance Registry System: N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide(851651-86-0)

Safety Data

• Hazardous Substances Data: 851651-86-0(Hazardous Substances Data)

Upstream product

• 99-09-2 3-nitro-aniline 
• 123-75-1 pyrrolidine 
• 625-36-5 2-chloropropionyl chloride 
• 60284-53-9 3-chloro-N-(3-nitrophenyl)propanamide 

Downstream Products

• 1070978-77-6 N-(3-azidophenyl)-3-(pyrrolidin-1-yl)propanamide 
• 1446421-10-8 N-(3-(3-(4-(bis(2-chloroethyl)amino)phenyl)ureido)phenyl)-3-(pyrrolidin-1-yl)propanamide 
• 1070978-30-1 5,5'-ureylene-di-(1-(3-(3-(pyrrolidin-1-yl)propanamido)-phenyl)-3-phenylurea) 
• 1070978-46-9 1,3-bis(4-(1-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 
• 1070977-78-4 1,3-bis(3-(3-(3-(pyrrolidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea 
• 1070977-92-2 1,3-bis(4-(3-(3-(pyrrolidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea 
• 1070978-36-7 1-(3-(1-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)-3-(3-(1-(3-(acrylamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 
• 1070978-34-5 1,3-bis(3-(1-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 
• 1070978-04-9 N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070979-17-7 1-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-3-(3-nitrophenyl)urea 
• 1070979-19-9 1-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-3-(3-aminophenyl)urea 
• 851651-87-1 N-(3-aminophenyl)-3-(pyrrolidin-1-yl)propanamide 

Relevant articles and documents

Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach

A series of new, water-soluble phenyl N-mustard-benzenealkylamide conjugates containing hydrophilic ω-dialkylaminoalkylamide or ω-cyclic aminoalkylamide moieties were synthesized via a bioisostere approach. These compounds have a broad spectrum of antitumor activity against a panel of human tumor cell lines. Of these derivatives, compound 18b effectively suppressed the growth of colon cancer (HCT-116), prostate cancer (PC3), and lung cancer (H460) xenografts. The growth of HCT-116 xenografts was almost completely suppressed when co-treated with compound 18b and 5-fluorouracil. Furthermore, compound 18b can induce DNA cross-linking and cell-cycle arrest at the G2/M phase. Early preclinical studies, including pharmacokinetics in rats, inhibition of the hERG, and 14 days of acute intravenous injection toxicity, suggest that compound 18b is a promising candidate for further preclinical studies.

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

UREYLENE DERIVATIVES

The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.