851916-84-2

Basic information

• Product Name: IMidazo[1,2-a]pyridine, 6-broMo-2-chloro-
• Synonyms: IMidazo[1,2-a]pyridine, 6-broMo-2-chloro-
• CAS NO: 851916-84-2
• Molecular Formula: C₇H₄BrClN₂
• Molecular Weight: 231.47706
• Mol File: 851916-84-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: IMidazo[1,2-a]pyridine, 6-broMo-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: IMidazo[1,2-a]pyridine, 6-broMo-2-chloro-(851916-84-2)
• EPA Substance Registry System: IMidazo[1,2-a]pyridine, 6-broMo-2-chloro-(851916-84-2)

Safety Data

• Hazardous Substances Data: 851916-84-2(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyridine, 6-bromo-2-chloro- is a chemical compound with the molecular formula C8H5BrClN2. It belongs to the class of imidazopyridines, which are heterocyclic compounds containing an imidazole ring fused to a pyridine ring. This chemical may be used in various chemical and pharmaceutical applications, including as a building block in the synthesis of pharmaceuticals and organic compounds. Its specific properties and potential uses may vary depending on the context and industry in which it is being used. Additionally, it is important to handle and store this chemical with proper safety precautions, as it may pose health and environmental risks if not handled properly.

Upstream product

• 1256037-96-3 C₇H₇BrN₂O₂ 
• 886436-47-1 6-bromo-imidazo[1,2-a]pyridin-2-one 
• 1072-97-5 5-bromo-2-pyridylamine 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1187820-68-3 [3-(2-chloroimidazo[1,2-a]pyridin-6-yl)phenyl]methanol 
• 1187820-69-4 [3-[2-(quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]phenyl]methanol 
• 1256033-74-5 N-(3-(3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-2-(1H-pyrazol-3-ylamino)imidazo[1,2-a]pyridin-6-yl)phenyl)acetamide 
• 1256033-62-1 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine 
• 1256034-21-5 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(3-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine 
• 1256033-63-2 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-methylphenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine 
• 1256037-99-6 C₁₇H₁₂ClFN₆ 
• 1187820-75-2 6-[3-[(tert-butyldimethylsilanyloxy)methyl]phenyl]-2-(1H-indol-6-yl)imidazo[1,2-a]pyridine 
• 1187820-74-1 6-[3-[(tert-butyldimethylsilanyloxy)methyl]phenyl]-2-chloroimidazo[1,2-a]pyridine 
• 1187820-76-3 {3-[2-(1H-indol-6-yl)imidazo[1,2-a]pyridin-6-yl]phenyl}methanol 

Relevant articles and documents

CONTROL METHOD FOR HARMFUL ARTHROPOD USING HETEROCYCLIC COMPOUND

PROBLEM TO BE SOLVED: To provide a control method for harmful arthropod. SOLUTION: A control method for harmful arthropod includes a process of applying the effective dose of a composition containing, for example, a compound of below-mentioned formula, or an N-oxide or agriculturally-acceptable salt thereof and one or more components selected from the group consisting of the below-mentioned group (a) to group (j) to the harmful arthropod, habitat thereof, plant or cultivation carrier of the plant. The groups (a) to (j) are as follow: (a): a group comprising insecticidal, mite-killing and nematode-killing active components; (b): disinfect active components; (c): plant growth-controlling components; (d): crop injury-reducing components; (e): synergist; (f): repellent components; (g): mollusk-killing components; (h): insect pheromone; (i): herbicidal active components; and (j): living matter-protective materials. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Pyrrolo-imidazo[1,2- A[pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

A new strategy for the construction of 3-phenyl-1H-pyrrolo-imidazo[1,2-a]pyridine backbone is described. The reaction starts from the coupling between N-tosylhydrazones and 2-chloro-3-nitroimidazo[1,2-a]pyridines leading to the formation of 3-nitro-2-(ary

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive mTOR inhibitors that demonstrate improved pharmacokinetic properties and selectivity compared to our previous leads. Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.