85218-66-2Relevant articles and documents
Multiple Functions Integrated inside a Single Molecule for Amplification of Photodynamic Therapy Activity
Shi, Xianqing,Zhan, Qichen,Li, Yanqing,Zhou, Lin,Wei, Shaohua
, p. 190 - 201 (2020)
Nitric oxide (NO) can play both prosurvival and prodeath roles in photodynamic therapy (PDT). The generation efficiency of peroxynitrite anions (ONOO-), by NO and superoxide anions (O2 ?-), significantly influenced the outcome. Reports indicated that such efficiency is closely related to the distance between NO and O2 ?-. Thus, in this manuscript, l-arginine (Arg) ethyl ester-modified zinc phthalocyanine (Arg-ZnPc) was designed and synthesized as a photosensitizer (PS) and NO donor. Post light irradiation, the guanido of Arg-ZnPc can be effectively oxidized by the generated reactive oxygen species (ROS) in the PDT process to release NO. Such a strategy could ensure O2 ?- and NO generation in the same place at the same time to guarantee effective ONOO- formation. In addition, NO has other multiple synergistic cancer treatment functions, including tumor tissue vasodilatation for drug extravasation promotion, P-glycoprotein (P-gp) downregulation for drug efflux inhibition, and glutathione depletion for cancer cell endogenous antioxidant defense destruction. In vitro and in vivo results indicated that the effective ONOO- formation and multiple functions of Arg-ZnPc could synergistically enhance its PDT activity and ensure satisfactory cancer treatment outcome.
Stably dispersed carbon nanotubes covalently bonded to phthalocyanine cobalt(II) for ppb-level H2S sensing at room temperature
Wu, Hao,Chen, Zhimin,Zhang, Jialin,Wu, Feng,He, Chunying,Wang, Bin,Wu, Yiqun,Ren, Zhiyu
, p. 1096 - 1104 (2016)
Cost-efficient, highly sensitive and stable sensing materials play a key role in developing H2S sensors. Herein, tetra-β-carboxyphenyloxyphthalocyanine cobalt(ii) (cPcCo) has been successfully bonded on the surface of acidified multiwalled carbon nanotubes (aCNTs) by a facile two-step condensation reaction in the presence of N,N′-dicyclohexylcarbodiimide (DCC), using hydroquinone (HQ), p-aminophenol (PAP), and p-phenylenediamine (PPD) as linking molecules, respectively. The obtained cPcCo-B-aCNT (B= HQ, PAP, and PPD) hybrids display good dispersibility in ethanol, which is beneficial to construct uniform sensing devices. The cPcCo-B-aCNT sensors, with a loose network-like structure, present abundant exposed sensing sites, oriented transmission of charges, and unimpeded pathways for H2S diffusion, which endow the cPcCo-B-aCNT hybrids with excellent sensing performance, in terms of sensitivity, reliability, reproducibility, and detection limit. The detection limit of the sensors composed of cPcCo-B-aCNT hybrids towards H2S reaches the ppb-level at room temperature, which is about the same as the odor threshold level for humans. For the cPcCo-HQ-aCNT sensor, the response to H2S varies linearly with respect to its concentration from 20 to 160 ppb and from 320 to 2560 ppb, with the highest gas response of 2.5% to 80 ppb H2S and a low detection limit of 5 ppb. Furthermore, the linking molecules play a critical role in the sensitivity of H2S, as evidenced from the current-voltage characteristics. The systematic study developed here provides a valid way to fabricate other high-efficient H2S sensors.
Synthesis of two novel water-soluble iron phthalocyanines and their application in fast chromogenic identification of phenolic pollutants
Gong, Jingjing,Li, Dapeng,Huang, Jun,Ding, Liyun,Tong, Yilin,Li, Kun,Zhang, Cong
, p. 487 - 497 (2014)
The novel water-soluble and sterically hindered phthalocyanine complexes, i.e. iron(III) tetra-(4-carboxyphenoxy) phthalocyanine (3) and iron(III) tetra-(8-quinolineoxy-5-sulfonicacid)phthalocyanine (4) were synthesized for fast detection of phenolic poll
Design of Turn-On Near-Infrared Fluorescent Probes for Highly Sensitive and Selective Monitoring of Biopolymers
Ducharme, Gerard T.,LaCasse, Zane,Nesterov, Evgueni E.,Nesterova, Irina V.,Sheth, Tanya
supporting information, p. 8440 - 8444 (2020/03/24)
Simple, sensitive, and selective detection of specific biopolymers is critical in a broad range of biomedical and technological areas. We present a design of turn-on near-infrared (NIR) fluorescent probes with intrinsically high signal-to-background ratio
