85259-19-4

Basic information

• Product Name: Methyl alpha-bromo-2-chlorophenylacetate
• Synonyms: a-Bromo-2-chlorobenzeneacetic Acid Methyl Ester;Methyl a-Bromo-2-chlorobenzeneacetat;Methyl a-Bromo-2-chlorophenylacetate;alpha-Bromo-2-chloro-phenylacetic acid methyl ester;Methyl alpha-bromo-2-chlorophenylacetate;Methyl α-Bromo-2-chlorobenzeneacetate;α-Bromo-2-chloro benzeneacetic Acid Methyl Ester;Methyl a-Bromo-2-chlorobenzeneacetate
• CAS NO: 85259-19-4
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.52
• EINECS: 617-693-6
• Product Categories: Chemical Activators;Activators
• Mol File: 85259-19-4.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 281 °C
• Flash Point: 124 °C
• Appearance: Light-Yellow Oil
• Density: 1.567
• Refractive Index: 1.5630 to 1.5670
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
• CAS DataBase Reference: Methyl alpha-bromo-2-chlorophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl alpha-bromo-2-chlorophenylacetate(85259-19-4)
• EPA Substance Registry System: Methyl alpha-bromo-2-chlorophenylacetate(85259-19-4)

Safety Data

• RIDADR: UN 3265 8/PG II
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 85259-19-4(Hazardous Substances Data)

Usage

Chemical Properties

Light-Yellow Oil

Uses

Methyl α-Bromo-2-chlorophenylacetate (cas# 85259-19-4) is a compound useful in organic synthesis.

InChI:InChI=1/C9H8BrClO2/c1-13-9(12)4-6-2-3-7(11)5-8(6)10/h2-3,5H,4H2,1H3

Upstream product

• 67-56-1 methanol 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 89-98-5 2-chloro-benzaldehyde 
• 10421-85-9 2-chloromandelic acid 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 138647-05-9 2-bromo-2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 85259-20-7 5-(2-chlorophenyl)-2-imino-1,3-thiazolidin-4-one 
• 767608-48-0 (2-Chloro-phenyl)-{4-[4-(4-cyano-phenyl)-thiazol-2-ylamino]-piperidin-1-yl}-acetic acid methyl ester 
• 181039-77-0 methyl (RS)-(5-allyloxy-2-cyanophenoxy)-(2-chlorophenyl)acetate 
• 181039-85-0 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]acetate 
• 181040-08-4 methyl (RS)-[5-(1,3-benzodioxol-5-ylmethoxy)-2-cyanophenoxy]-(2-chlorophenyl)acetate 
• 141109-25-3 (S)-(+)-2-bromo-2-(2-chlorophenyl)acetic acid 
• 622835-93-2 (R)-2-bromo-2-(2-chlorophenyl)acetic acid methyl ester 
• 90055-48-4 clopidogrel 
• 181039-78-1 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-hydroxyphenoxy]acetate 
• 181039-80-5 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridin-4-ylmethoxy)phenoxy]acetate 
• 181040-28-8 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate 
• 181040-41-5 methyl (RS)-[5-(benzoxazol-6-ylmethoxy)-2-cyanophenoxy]-(2-chlorophenyl)acetate 

Relevant articles and documents

Method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling aqueous solution method

The invention provides a method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling an aqueous solution method. According to the method, o-chlorophenylacetic acid is adopted as a main raw material, an organic solvent and water in an appropriate proportion are optimized to serve as a bromination mixed solvent, a two-phase reaction mode is adopted in the reaction process, a bromine-containing wastewater solution can be reused without complex treatment, a target product is prepared through bromination and esterification reactions, and the yield reaches78% or above; the method provided by the invention is based on a technical scheme of recycling an aqueous solution containing a bromination reagent. In the process production process, the input amountof a new bromination reagent is reduced to a great extent, the bromine atom utilization rate of the bromination reagent is increased, the problems of wastewater treatment and discharge are reduced, the pressure of environmental pollution is reduced, meanwhile, the reaction conditions are relatively mild, treatment is simple, and industrial production is facilitated.

COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as tocompositions and ophthalmic devices comprising such compounds.

Synthesis method of clopidogrel hydrogen sulfate

The invention discloses a synthesis method of clopidogrel hydrogen sulfate. The synthesis method takes o-phenylphthalic chloroacetic acid and 4,5,6,7tetrahydrothiophene[3,2-c] as raw materials and comprises the following steps: (1) carrying out acylation reaction; (2) carrying out bromination reaction; (3) carrying out esterification reaction; (4) preparing a clopidogrel base crude product; (5) extracting clopidogrel base; (5) carrying out racemic racemate reductionresolution; (7) preparing the clopidogrel hydrogen sulfate. According to the synthesis method of the clopidogrel hydrogen sulfate, disclosed by the invention, reasonable raw material selection and process route design are carried out, so that on one hand, a process flow is simplified and synthesis operation is easy to realize; on the other hand, reaction conditions are reduced, the reaction conditions are moderate and the method is easily smoothly carried out; the obtained finished product clopidogrel hydrogen sulfate has high yield and good quality; industrial production is easy to realize and a market prospect is wide.