85333-43-3

Basic information

• Product Name: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE
• Synonyms: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE;8-chloro-2-MethyliMidazo[1;8-Chloro-2-MethyliMidazol[1,2-a]pyrazine
• CAS NO: 85333-43-3
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.6
• Mol File: 85333-43-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.43 g/cm³
• Refractive Index: 1.681
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.51±0.30(Predicted)
• CAS DataBase Reference: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE(85333-43-3)
• EPA Substance Registry System: 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE(85333-43-3)

Safety Data

• Hazardous Substances Data: 85333-43-3(Hazardous Substances Data)

Usage

General Description

8-Chloro-2-methylimidazo[1,2-a]pyrazine is a chemical compound with the molecular formula C6H5ClN4. It belongs to the class of organic compounds known as pyrazines, which are aromatic heterocyclic compounds containing a five-membered ring made up of three carbon atoms and two nitrogen atoms. 8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE is a chloro-substituted derivative of 2-methylimidazo[1,2-a]pyrazine and is commonly used in the pharmaceutical and agricultural industries. It is known to have mutagenic and genotoxic properties and is often used in research to study DNA damage and mutations. In addition, it is also used as a flavoring agent in food products and as an intermediate in the synthesis of various biologically active compounds.

InChI:InChI=1/C7H6ClN3/c1-5-4-11-3-2-9-6(8)7(11)10-5/h2-4H,1H3

Upstream product

• 6863-73-6 3-chloropyrazin-2-amine 
• 78-95-5 chloroacetone 
• 126-38-5 1-bromo-2,2-dimethoxypropane 

Downstream Products

• 110206-70-7 3-amino-2-methyl-8-(2-phenylethyl)imidazo<1,2-a>pyrazine 
• 1334166-66-3 3-[1-(2-chlorobenzyl)-1H-pyrazol-4-yl]-2-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine 
• 1436383-95-7 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol 
• 1124321-01-2 4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol 
• 1124320-61-1 4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide 
• 1436383-97-9 3-bromo-2-methyl-N-[(3-methylsulfonylphenyl)methyl]imidazo[1,2-a]pyrazin-8-amine 
• 1124321-37-4 4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide 
• 1124321-36-3 3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine 

Relevant articles and documents

SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia

We report the discovery of a series of imidazo[1,2-a]pyrazine derivatives as novel inhibitors of phosphodiesterase 10A (PDE10A). In a high-throughput screening campaign we identified the imidazopyrazine derivative 1, a PDE10A inhibitor with limited select

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections

Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIIIβ. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.