85380-93-4

Basic information

• Product Name: 1-bismethylthio-2-chloro-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene
• CAS NO: 85380-93-4
• Molecular Weight: 351.921
• Mol File: 85380-93-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-bismethylthio-2-chloro-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bismethylthio-2-chloro-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene(85380-93-4)
• EPA Substance Registry System: 1-bismethylthio-2-chloro-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene(85380-93-4)

Safety Data

• Hazardous Substances Data: 85380-93-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 85380-92-3 1-(methylsulfinyl)-1-methylthio-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene 
• 63833-44-3 morpholino(p-tolyl)methanone 
• 62128-31-8 (1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone 
• 75820-72-3 1-metil-5-p-metilbenzoil-1H-pirrolo-2-carbossialdeide 
• 96-54-8 N-Methylpyrrole 

Relevant articles and documents

Non-steroidal antiinflammatory agents. 1. A novel synthesis of 1-methyl-5-p-tolylpyrrole-2-acetic acid (tolmetin)

A four-step preparation of 1-methyl-5-p-tolylpyrrole-2-acetic acid (Tolmetin) is reported starting from 1-methyl-2-p-tolylpyrrole. Formylation of this compound followed by condensation with methyl(methylthio)methyl sulfoxide furnished 1-(methylsulfinyl)-1-methylthio-2-(1-methyl-5-p-tolyl-2-pyrrolyl)ethylene. Pummerer rearrangement of the latter compound gave ethyl 1-methyl-5-p-tolypyrrole-2-acetate, which was hydrolyzed in alkaline medium to afford Tolmetin.