854472-60-9Relevant articles and documents
Synthesis and biological evaluation of potent bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT) lacking a nitro group
Paulini, Ralph,Lerner, Christian,Diederich, Francois,Jakob-Roetne, Roland,Zuercher, Gerhard,Borroni, Edilio
, p. 1856 - 1887 (2007/10/03)
Inhibition of the enzyme catechol O-methyltransferase (COMT) represents a viable strategy for regulation of the catabolism of catecholamine neurotransmitters or their precursors, and is of considerable interest in the therapy of Parkinson's, disease. Here