85448-89-1

Basic information

• Product Name: 2'-METHYL-4-METHOXY DIPHENYL AMINE
• Synonyms: 2'-Methyl-4-methoxydiphenylamine;N-(4-methoxyphenyl)-2-methylaniline
• CAS NO: 85448-89-1
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.28
• Mol File: 85448-89-1.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 344.6 °C at 760 mmHg
• Flash Point: 140.1 °C
• Appearance: /
• Density: 1.089 g/cm³
• CAS DataBase Reference: 2'-METHYL-4-METHOXY DIPHENYL AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYL-4-METHOXY DIPHENYL AMINE(85448-89-1)
• EPA Substance Registry System: 2'-METHYL-4-METHOXY DIPHENYL AMINE(85448-89-1)

Safety Data

• Hazardous Substances Data: 85448-89-1(Hazardous Substances Data)

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 104-94-9 4-methoxy-aniline 
• 95-49-8 2-methylchlorobenzene 
• 696-62-8 para-iodoanisole 
• 95-53-4 o-toluidine 
• 1134-92-5 o-tolyl N,N-dimethylsulfamate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-17-4 para-methoxynitrobenzene 
• 95-46-5 2-methylphenyl bromide 
• 1516-21-8 4-methoxynitrosobenzene 
• 95-48-7 ortho-cresol 
• 583-60-8 2-Methylcyclohexanone 
• 16419-60-6 2-Methylphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 

Relevant articles and documents

N-Heterocyclic Carbene Palladium(II) Amine Complexes: The Role of Primary Aryl- or Alkylamine Binding and Applications in the Buchwald-Hartwig Amination Reaction

N-heterocyclic carbene-palladium(II) amine complexes bearing primary aryl- or alkylamines were synthesized. The prepared complexes were characterized by single crystal X-ray diffraction as well as NMR spectroscopy. These complexes exhibited good catalytic activities for the Buchwald-Hartwig amination reaction of aryl chlorides to afford arylated anilines under mild conditions. All reactions were carried out in air and all starting materials were used as supplied without purification. 21 expected coupling products were obtained in moderate to high yields under optimum conditions.

Continuous Synthesis of Aryl Amines from Phenols Utilizing Integrated Packed-Bed Flow Systems

Aryl amines are important pharmaceutical intermediates among other numerous applications. Herein, an environmentally benign route and novel approach to aryl amine synthesis using dehydrative amination of phenols with amines and styrene under continuous-flow conditions was developed. Inexpensive and readily available phenols were efficiently converted into the corresponding aryl amines, with small amounts of easily removable co-products (i.e., H2O and alkanes), in multistep continuous-flow reactors in the presence of heterogeneous Pd catalysts. The high product selectivity and functional-group tolerance of this method allowed aryl amines with diverse functional groups to be selectively obtained in high yields over a continuous operation time of one week.

Palladate Precatalysts for the Formation of C-N and C-C Bonds

A series of imidazolium-based palladate precatalysts has been synthesized and the catalytic activity of these air- and moisture-stable complexes evaluated as a function of the nature of the imidazolium counterion. These precatalysts can be converted under