85462-59-5

Basic information

• Product Name: 2-Bromo-5-chloro-4-fluoroaniline
• Synonyms: 2-BROMO-5-CHLORO-4-FLUOROANILINE;2-Bromo-4-fluoro-5-chloroaniline;2-bromo-5-chloro-4-fluorobenzenamine;1-Amino-2-bromo-5-chloro-4-fluorobenzene;BroMo-5-chloro-4-fluoroaniline;3-broMo-5-chloro-2-fluorobenzenaMine
• CAS NO: 85462-59-5
• Molecular Formula: C₆H₄BrClFN
• Molecular Weight: 224.46
• Mol File: 85462-59-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 272.5 °C at 760 mmHg
• Flash Point: 118.6 °C
• Appearance: /
• Density: 1.809 g/cm³
• Vapor Pressure: 0.00605mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.54±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-chloro-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-chloro-4-fluoroaniline(85462-59-5)
• EPA Substance Registry System: 2-Bromo-5-chloro-4-fluoroaniline(85462-59-5)

Safety Data

• Hazardous Substances Data: 85462-59-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-chloro-4-fluoroaniline is a chemical compound with the molecular formula C6H4BrClFN and a molecular weight of 206.46 g/mol. It is a substituted aniline derivative with bromine, chlorine, and fluorine atoms attached to the benzene ring. 2-Bromo-5-chloro-4-fluoroaniline is used in various chemical reactions and synthesis processes, as well as in the production of pharmaceuticals and agrochemicals. 2-Bromo-5-chloro-4-fluoroaniline is known to have potential health hazards, so proper handling and safety precautions are necessary when working with this chemical.

InChI:InChI=1/C6H4BrClFN/c7-3-1-5(9)4(8)2-6(3)10/h1-2H,10H2

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 868408-85-9 6-(2-bromo-5-chloro-4-fluoro-phenyl)-4,6-diaza-spiro[2.4]heptane-5,7-dione 
• 937816-87-0 1-(2-amino-4-chloro-5-fluorophenyl)ethanone 
• 1015427-16-3 2-amino-4-chloro-5-fluorobenzonitrile 
• 231297-42-0 methyl (2E)-3-{4-chloro-5-fluoro-2-[(phenylsulfonyl)amino]phenyl}acrylate 
• 231297-40-8 methyl (2E)-3-(2-amino-4-chloro-5-fluorophenyl)acrylate 
• 916799-45-6 N,N-di-tert-butyloxycarbonyl-2-bromo-5-chloro-4-fluoro-aniline 
• 122509-72-2 6-Chloro-5-fluoro-1H-indole 
• 496916-77-9 3-chloro-4-fluoro-6-vinylaniline 

Relevant articles and documents

FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY

The present invention provides a compound of formula (I), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity,

Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug

Cyclooxygenase (COX) is a key rate-limiting enzyme for prostaglandin (PG) production cascades in the human body. The mechanisms of both the anti-inflammation effects and the side-effects of traditional COX inhibitors are associated with the existence of two COX isoforms. Thus while COX-1 is predominantly expressed ubiquitously and constitutively, and it serves a housekeeping role in processes such as gastrointestinal (GI) mucosa protection, COX-2 is absent or exhibits a low level of expression in most tissues, and is highly upregulated in response to endotoxin, virus, inflammatory or tissue-injury stimuli/signals, and tumour promoter in the various types of organs, tissues, and cells. Furthermore, COX-2 contribution to PGE2 and PGI2 production evokes and sustains systemic or peripheral inflammatory disease, but it is not involved in the COX-1-mediated GI tract events. Also, hypersensitivity of aspirin owing to its inhibitory action against COX-1 is a significant concern clinically. Consequently, highly selective COX-2 inhibitors have been needed for the treatment of inflammatory- and inflammation related-diseases that include pyrexia, inflammation, pain, rheumatoid arthritis, osteoarthritis, and cancers. In this study, a series of novel [2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted or 5,6-disubstituted)-1H-indol-3-yl]acetic acid analogues was designed, synthesized, and evaluated to identify potent and selective COX-2 inhibitors as potential agents against inflammatory diseases. As significant findings, the present study clarified unique structure-activity relationship of the analogues toward potent and selective COX-2 inhibition in vitro, and identified 2-{6-fluoro-2-[4-methyl-2-pridinyl)carbonyl]-1H-indol-3-yl}acetic acid as a potent and selective COX-2 inhibitor in vitro that demonstrated orally potent anti-inflammation efficacy against carrageenan-induced oedema formation in the foot of SPF/VAF male SD rats as a peripheral inflammation model in vivo.

Preparation of 6-chloro-5-fluoroindole via the use of palladium and copper-mediated heterocyclisations

The title indole, the heterocyclic core of the 5-HT2C receptor agonist Ro 60-0175, was prepared by a modification to the Stille indole synthesis, or by the method of Gonzalez and co-workers.