85623-70-7

Basic information

• Product Name: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide
• Synonyms: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide;N-tert-Butyl-4-fluorobenzenemethanimine N-oxide
• CAS NO: 85623-70-7
• Molecular Formula: C₁₁H₁₄FNO
• Molecular Weight: 195.23
• Mol File: 85623-70-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(85623-70-7)
• EPA Substance Registry System: N-[(4-Fluorophenyl)methylene]-2-methyl-2-propanamine N-oxide(85623-70-7)

Safety Data

• Hazardous Substances Data: 85623-70-7(Hazardous Substances Data)

Upstream product

• 91416-53-4 2-(tert-butyl)-3-(4-fluorophenyl)-1,2-oxaziridine 
• 125640-89-3 N-(4-fluorobenzyl)-tert-butylamine 
• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 594-70-7 2-Methyl-2-nitropropane 
• 16649-50-6 N-tert-Butylhydroxylamine 

Downstream Products

• 112852-96-7 5-fluoro-2, 3-diphenyl-1H-inden-1-one 
• 2406-25-9 di-tert-butyl nitroxide 
• 95449-00-6 C₁₇H₁₉FNO 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Iridium-Catalyzed Direct C-H Sulfamidation of Aryl Nitrones with Sulfonyl Azides at Room Temperature

Ir(III)-catalyzed direct C-H sulfamidation of aryl nitrones has been developed to synthesize various sulfamidated nitrones in moderate to excellent yields with excellent regioselectivity and broad functional group tolerance. This transformation could proceed smoothly at room temperature with low catalyst loading in the absence of external oxidants, acids, or bases. Molecular nitrogen was released as the sole byproduct, thus providing an environmentally benign sulfamidation process. And this protocol could efficiently apply to synthesize the substituted benzisoxazoline via one-step transformation from the product.

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright

COMPOSITIONS AND METHODS OF INHIBITING RETINAL DEGENERATION

Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compos