85661-17-2Relevant articles and documents
An Application of the Mannich Reaction Using Hydroxylamine and Some of its Derivatives. 6-Substituted-2,4-diamino-5,6,7,8-tetrahydropyrimidopyrimidines
Delia, Thomas J.,Kirt, Diane D.,Sami, Salah M.
, p. 145 - 147 (2007/10/02)
Hydroxylamine and some of its O-substituted derivatives (2) have been used as the amine component in Mannich reactions with 2,4,6-triaminopyrimidine (1).The resulting 6-substituted tetrahydropyrimidopyrimidines (3) contain an N-O bond linking the substituent to the ring.These results extend the utility of this modified Mannich reaction to otherwise inaccessible substituents.Reaction conditions, spectral data and certain limitations of the reaction are discussed.