85666-17-7 Usage
Description
U-63557A, also known as Furegrelate Sodium, is a selective and potent thromboxane A2 synthase (TXA2R) inhibitor in platelets. It is a pharmaceutical compound that has the ability to inhibit the production of thromboxane A2, a potent vasoconstrictor and platelet aggregator, which plays a significant role in the pathophysiology of various cardiovascular diseases.
Uses
Used in Pharmaceutical Industry:
U-63557A is used as a therapeutic agent for the treatment of cardiovascular diseases, particularly those involving platelet aggregation and vasoconstriction. Its ability to selectively inhibit thromboxane A2 synthase in platelets makes it a promising candidate for the management of conditions such as atherosclerosis, thrombosis, and other related disorders.
Used in Research Applications:
U-63557A is also utilized as a research tool in the study of platelet function, thromboxane A2 synthesis, and related signaling pathways. Its selective inhibition of TXA2R allows researchers to investigate the role of thromboxane A2 in various physiological and pathological processes, contributing to a better understanding of the underlying mechanisms and potential therapeutic targets in cardiovascular medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 85666-17-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,6,6 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 85666-17:
(7*8)+(6*5)+(5*6)+(4*6)+(3*6)+(2*1)+(1*7)=167
167 % 10 = 7
So 85666-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H11NO3.Na/c17-15(18)14-8-12-7-10(3-4-13(12)19-14)6-11-2-1-5-16-9-11;/h1-5,7-9H,6H2,(H,17,18);/q;+1/p-1
85666-17-7Relevant articles and documents
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids.
Johnson,Nidy,Aiken,Crittenden,Gorman
, p. 1461 - 1468 (1986)
The synthesis and screening of a series of 5-(3-pyridylmethyl)benzofuran-2-carboxylic acids as selective thromboxane A2 (TxA2) synthase inhibitors is outlined. The ability of these compounds to inhibit TxA2 biosynthesis was assayed using microsomal enzyme