856957-26-1

Basic information

• Product Name: A-(3-BROMOPHENYL)-2-PYRIDINEMETHANOL
• Synonyms: 2-PYRIDINEMETHANOL, A-(3-BROMOPHENYL)-;A-(3-BROMOPHENYL)-2-PYRIDINEMETHANOL;2-Pyridinemethanol,α-(3-bromophenyl)-;(3-bromophenyl)(pyridin-2-yl)methanol
• CAS NO: 856957-26-1
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.121
• Mol File: 856957-26-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 384.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.496±0.06 g/cm3(Predicted)
• PKA: 12.59±0.20(Predicted)
• CAS DataBase Reference: A-(3-BROMOPHENYL)-2-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: A-(3-BROMOPHENYL)-2-PYRIDINEMETHANOL(856957-26-1)
• EPA Substance Registry System: A-(3-BROMOPHENYL)-2-PYRIDINEMETHANOL(856957-26-1)

Safety Data

• Hazardous Substances Data: 856957-26-1(Hazardous Substances Data)

Upstream product

• 98-98-6 2-Picolinic acid 
• 3132-99-8 m-bromobenzoic aldehyde 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 1013031-71-4 1-bromo-3-[1-methoxy-1-(2-pyridyl)methyl]benzene 
• 206357-82-6 (3-bromophenyl)(pyridin-2-yl)methanone 
• 1613186-49-4 2-[(3-bromophenyl)(hydrazono)methyl]pyridine 
• 1613186-54-1 3-(3-bromophenyl)-[1,2,3]triazolo[1,5-a]pyridine 

Relevant articles and documents

Facile one-pot synthesis of [1,2,3]triazolo[1,5-a]pyridines from 2-acylpyridines by copper(II)-catalyzed oxidative N-N bond formation

An efficient and simple method for the synthesis of various [1,2,3]triazolo[1,5-a]pyridines has been established. The method involves a copper(II)-catalyzed oxidative N-N bond formation that uses atmospheric oxygen as the terminal oxidant following hydrazonation in one pot. The use of ethyl acetate as the solvent dramatically promotes the oxidative N-N bond-formation reaction and enables the application of oxidative cyclization in the efficient one-pot reaction. A mechanism for the reaction was proposed on the basis of the results of a spectroscopic study. In the same pot: [1,2,3]Triazolo[1,5-a] pyridines are synthesized from the corresponding 2-acylpyridines by a one-pot method, consisting of hydrazonation followed by oxidative cyclization through copper(II)-catalyzed N-N bond formation (see scheme).

FUSED RING HETEROCYCLE KINASE MODULATORS

The present invention provides fused ring heterocycles as kinase modulators, pharmaceutical compositions containing these modulators, and methods of using these modulators to treat diseases mediated by kinase activity.