857887-02-6

Basic information

• Product Name: 4-Bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester
• Synonyms: 4-Bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester
• CAS NO: 857887-02-6
• Molecular Weight: 636.583
• Mol File: 857887-02-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester(857887-02-6)
• EPA Substance Registry System: 4-Bromo-benzoic acid 2-(cyano-hydroxy-methyl)-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester(857887-02-6)

Safety Data

• Hazardous Substances Data: 857887-02-6(Hazardous Substances Data)

Upstream product

• 478012-72-5 4-bromo-benzoic acid 2,2-dimethyl-4H-benzo[1,3]dioxin-5-ylmethyl ester 
• 478012-73-6 4-bromo-benzoic acid 3-hydroxy-2-hydroxymethyl-benzyl ester 
• 478012-53-2 4-bromo-benzoic acid 2-formyl-3-hydroxy-benzyl ester 
• 112429-70-6 (2,2-dimethyl-4H-benzo[d][1,3]dioxin-5-yl)methanol 
• 586-75-4 4-chlorobenzoyl chloride 
• 857651-83-3 4-Bromo-benzoic acid 3-((E)-4-acetoxy-2-methyl-but-2-enyloxy)-2-formyl-benzyl ester 
• 857651-84-4 4-Bromo-benzoic acid 3-((E)-4-bromo-2-methyl-but-2-enyloxy)-2-formyl-benzyl ester 
• 857652-14-3 4-Bromo-benzoic acid 2-formyl-3-((E)-4-hydroxy-2-methyl-but-2-enyloxy)-benzyl ester 
• 857651-85-5 4-Bromo-benzoic acid 2-formyl-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester 
• 5804-85-3 diethylaluminium cyanide 

Downstream Products

• 857652-15-4 4-Bromo-benzoic acid 2-cyanocarbonyl-3-{(E)-4-[4-methoxy-6-methyl-1-(3-methyl-but-2-enyl)-2-oxo-cyclohex-3-enyl]-2-methyl-but-2-enyloxy}-benzyl ester 

Relevant articles and documents

The total synthesis of coleophomones B, C, and D

Members of the coleophomone family of natural products all possess several intriguing and challenging architectural features, as well as exhibit unusual biological activity. They, therefore, constitute attractive targets for synthesis. In this Article, we describe the total synthesis of coleophomones B (2), C (3), and D (4). The highly strained and congested 11-membered macrocycle of coleophomones B (2) and C (3) was constructed using an impressive olefin metathesis reaction. Furthermore, both of the requisite geometric isomers of the Δ within the macrocycle could be accessed from a common precursor, facilitating a divergence that lent the coleophomone B (2)/C (3) synthesis an unusually high degree of efficiency. The synthesis of coleophomone D (4) confirmed that it exists as a dynamic mixture of isomeric forms with a different aromatic substitution pattern from the other family members.