858516-27-5

Basic information

• Product Name: 2-Bromo-N-cyclohexylbenzenamine
• Synonyms: 2-Bromo-N-cyclohexylbenzenamine;BenzenaMine, 2-broMo-N-cyclohexyl-
• CAS NO: 858516-27-5
• Molecular Formula: C₁₂H₁₆BrN
• Molecular Weight: 254.17
• Mol File: 858516-27-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.355
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Bromo-N-cyclohexylbenzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-cyclohexylbenzenamine(858516-27-5)
• EPA Substance Registry System: 2-Bromo-N-cyclohexylbenzenamine(858516-27-5)

Safety Data

• Hazardous Substances Data: 858516-27-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-cyclohexylbenzenamine, also known as 2-bromocyclohexylphenylamine, is an organic chemical compound with the molecular formula C12H14BrN. It is a brominated aniline derivative with a cyclohexyl group attached to the amino nitrogen. 2-Bromo-N-cyclohexylbenzenamine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a building block for the preparation of various functionalized cyclohexylphenylamines, which have potential applications in medicinal chemistry. 2-Bromo-N-cyclohexylbenzenamine is a solid compound with a white to off-white appearance and is typically handled and stored in a controlled environment due to its potentially hazardous nature.

Upstream product

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Downstream Products

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Relevant articles and documents

Decarboxylative sp 3 C-N coupling via dual copper and photoredox catalysis

Over the past three decades, considerable progress has been made in the development of methods to construct sp 2 carbon-nitrogen (C-N) bonds using palladium, copper or nickel catalysis 1,2 . However, the incorporation of alkyl substrates to form sp 3 C-N bonds remains one of the major challenges in the field of cross-coupling chemistry. Here we demonstrate that the synergistic combination of copper catalysis and photoredox catalysis can provide a general platform from which to address this challenge. This cross-coupling system uses naturally abundant alkyl carboxylic acids and commercially available nitrogen nucleophiles as coupling partners. It is applicable to a wide variety of primary, secondary and tertiary alkyl carboxylic acids (through iodonium activation), as well as a vast array of nitrogen nucleophiles: nitrogen heterocycles, amides, sulfonamides and anilines can undergo C-N coupling to provide N-alkyl products in good to excellent efficiency, at room temperature and on short timescales (five minutes to one hour). We demonstrate that this C-N coupling protocol proceeds with high regioselectivity using substrates that contain several amine groups, and can also be applied to complex drug molecules, enabling the rapid construction of molecular complexity and the late-stage functionalization of bioactive pharmaceuticals.

Enantioselective synthesis of 2-methyl indolines by palladium catalysed asymmetric C(sp3)-H activation/cyclisation

The first example of the enantioselective methyl C-H activation by an intramolecular ArPdX species and subsequent cyclisation was developed. Palladium catalysts using commercially available chiral diphosphines yield good ee's (up to 93% ee) in the synthesis of 2-methyl indolines from 2-halo N-isopropyl anilides. This approach was also employed for the synthesis of enantioenriched cyclohexyl fused indolines with moderate enantioselectivities.

Transition Metal Complexes and Preparation Methods Thereof

The present invention provides a novel mononuclear transition metal compound, a novel binuclear transition metal compound, a novel organic amine or phosphorous compound, and a method for preparing the same. The mononuclear transition metal compound accord