858643-92-2

Basic information

• Product Name: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-3-acetylpiperidine;tert-butyl 3-acetylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-diMethylethyl ester;3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester
• CAS NO: 858643-92-2
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.30004
• EINECS: 200-589-5
• Mol File: 858643-92-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 312.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.052
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.40±0.40(Predicted)
• CAS DataBase Reference: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(858643-92-2)
• EPA Substance Registry System: 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(858643-92-2)

Safety Data

• Hazardous Substances Data: 858643-92-2(Hazardous Substances Data)

Usage

General Description

3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is a chemical compound used in the synthesis of pharmaceuticals and organic molecules. It is a derivative of piperidine, a six-membered heterocyclic ring containing nitrogen, and contains an acetyl group and a tert-butyl ester functional group. 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester is a key intermediate in the production of various drugs and can be used as a building block in the creation of complex organic molecules. Its unique structure and reactivity make it a valuable tool in the development of new pharmaceuticals and organic compounds. Overall, 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester plays a crucial role in the field of synthetic organic chemistry and drug discovery.

Upstream product

• 676-58-4 methylmagnesium chloride 
• 148672-74-6 ethyl N-(t-butyloxycarbonyl)nipecotate 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 
• 1008562-93-3 (S)-3-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 75-16-1 methylmagnesium bromide 
• 189442-78-2 (±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 

Downstream Products

• 1235439-55-0 3-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1188264-16-5 tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate 
• 1374353-21-5 tert-butyl 3-(1-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate 
• 1374351-14-0 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole 
• 377780-25-1 3-(1-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds,

[1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are useful for the treatment of diabetes and obesity.