859163-61-4Relevant articles and documents
A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells
Paleek, Jii,Zweigerdt, Robert,Olmer, Ruth,Martin, Ulrich,Kirschning, Andreas,Draeger, Gerald
experimental part, p. 5503 - 5510 (2011/08/10)
A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro deriv
Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation
Hanano, Tokushi,Adachi, Kunitomo,Aoki, Yoshiyuki,Morimoto, Hiroshi,Naka, Yoichi,Hisadome, Masao,Fukuda, Tetsuko,Sumichika, Hiroshi
, p. 881 - 884 (2007/10/03)
A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpipe
