859809-34-0Relevant articles and documents
Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3- thiophenecarboxamides
Bonafoux, Dominique,Bonar, Sheri,Christine, Lori,Clare, Michael,Donnelly, Ann,Guzova, Julia,Kishore, Nandini,Lennon, Patrick,Libby, Adam,Mathialagan, Sumathy,McGhee, William,Rouw, Sharon,Sommers, Cindy,Tollefson, Michael,Tripp, Catherine,Weier, Richard,Wolfson, Serge,Min, Yao
, p. 2870 - 2875 (2005)
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3- thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition of th