86031-18-7

Basic information

• Product Name: 4-allyl-1-hydroxy-2-methoxy-5-nitrobenzene
• Synonyms: 4-allyl-1-hydroxy-2-methoxy-5-nitrobenzene
• CAS NO: 86031-18-7
• Molecular Weight: 209.202
• Mol File: 86031-18-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-allyl-1-hydroxy-2-methoxy-5-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-allyl-1-hydroxy-2-methoxy-5-nitrobenzene(86031-18-7)
• EPA Substance Registry System: 4-allyl-1-hydroxy-2-methoxy-5-nitrobenzene(86031-18-7)

Safety Data

• Hazardous Substances Data: 86031-18-7(Hazardous Substances Data)

Upstream product

• 93-28-7 eugenol acetate 
• 77566-54-2 4-allyl-5-nitro-1,2-methylenedioxybenzene 
• 97-53-0 4-allylguaiacol 
• 501008-26-0 1-allyl-4-benzyloxy-5-methoxy-2-nitro-benzene 
• 57371-42-3 4-allyl-1-benzyloxy-2-methoxybenzene 

Downstream Products

• 714251-84-0 (4-hydroxy-5-methoxy-2-nitro-phenyl)-acetic acid 
• 76936-55-5 4-allyl-1,2-dimethoxy-5-nitrobenzene 
• 858258-05-6 1-acetoxy-4-allyl-2-methoxy-5-nitro-benzene 

Relevant articles and documents

Synthesis, activity, and docking studies of eugenol-based glucosides as new agents against Candida sp.

Seventeen new synthetic derivatives of eugenol (6, 8–15 and 8′-15′) were planned following literature reports on antifungal activities of nitroeugenol and eugenol glucoside. The anti-Candida activity of these compounds was investigated by in vitro assay, and the cytotoxicity evaluation was performed with the most active compounds. The peracetylated glucosides presented better biological results than their hydroxylated analogues. The glucoside 11, a 4-nitrobenzamide, showed the best potency (MIC50 range 11.0–151.84?μm), the wider spectrum of action, and overall the best selectivity indexes, especially against C.?tropicalis (~30) and C.?krusei (~15). To investigate its possible mechanism of action, glucoside 11 was subjected to molecular docking studies with Candida sp. enzymes involved in ergosterol biosynthesis. Results have shown that the peracetyl glucosyl moiety and the 4-nitrobenzamide group in 11 are effectively involved in its high affinity with the active site of squalene epoxidase.

Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line

Cancer is one of the most critical problems of public health in the world and one of the main challenges for medicine. Different biological effects have been reported for sulfonamide-based compounds including antibacterial, antifungal, and antitumor activ

SELECTIVE NITRATION OF PHENOLS CATALYZED BY LANTHANUM (III) NITRATE

Phenols are easily mononitrated at room temperature by NaNO3 in a two-phase system (water - ether) in presence of HCl and a catalytic amount of La(NO3)3.The experimental conditions leave completely unaltered many other aromatic systems.