860742-51-4

Basic information

• Product Name: 4-Chloro-o-acetophenetide
• Synonyms: 4-Chloro-o-acetophenetide
• CAS NO: 860742-51-4
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.66078
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 860742-51-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-o-acetophenetide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-o-acetophenetide(860742-51-4)
• EPA Substance Registry System: 4-Chloro-o-acetophenetide(860742-51-4)

Safety Data

• Hazardous Substances Data: 860742-51-4(Hazardous Substances Data)

Usage

Uses

4-Chloro-o-acetophenetide (cas# 860742-51-4) is a compound useful in organic synthesis.

Upstream product

• 7647-01-0 hydrogenchloride 
• 581-08-8 2'-ethoxyacetanilide 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 64-19-7 acetic acid 
• 28443-50-7 2-amino-5-chlorophenol 
• 74-96-4 ethyl bromide 
• 16323-09-4 N-(4-chloro-2-hydroxyphenyl)acetamide 
• 108-24-7 acetic anhydride 
• 610-67-3 1-ethoxy-2-nitrobenzene 

Downstream Products

• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 
• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 

Relevant articles and documents

New synthesis of N-(4-chloro-3-cyano-7-ethoxyquinolin- 6-yl)acetamide

New synthetic route of N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)- acetamide (1) is described on a hectogram scale. The key steps include the intramolecular cyclization of 3-amino-2-(2-chlorobenzoyl)acrylonitrile 22 to give the 3-cyano-4-quinolone 7, which was chlorinated by POCl3 to give the final product 1 in 36.9% yield over 9 steps and 98.9% purity (HPLC). Purification methods of 7 and 1 were also given.