862549-18-6Relevant articles and documents
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C
Kang, Ji-Hye,Peach, Megan L.,Pu, Yongmei,Lewin, Nancy E.,Nicklaus, Marc C.,Blumberg, Peter M.,Marquez, Victor E.
, p. 5738 - 5748 (2007/10/03)
Diacylglycerol (DAG) lactones with altered functionality (C=O → CH2 or C=O → C=S) at the sn-1 and sn-2 carbonyl pharmacophores were synthesized and used as probes to dissect the individual role of each carbonyl in the binding to protein kinase