863029-89-4

Basic information

• Product Name: (S)-4-Desmethoxy-4-chloro Omeprazole
• Synonyms: 5-Methoxy-2-{(S)-[(4-Chloro-3,5-dimethyl-pyridine-2-yl)methyl]sulfinyl}-1H-benzimidazol;(S)-4-Desmethoxy-4-chloro Omeprazole;2-[[(4-Chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole;5-Methoxy-2-[(S)-[(4-Chloro-3,5-dimethyl-pyridine-2-yl)methyl]sulfinyl]-1H-benzimidazole;4-DesMethoxy-4-chloro OMeprazole;5-Methoxy-2-[[(4-Chloro-3,5-diMethyl-pyridine-2-yl)Methyl]sulfinyl]-1H-benziMidazole;2-[[(4-Chloro-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1H-benzimidazole;OMeprazole IMpurity – H (EP)
• CAS NO: 863029-89-4
• Molecular Formula: C16H16ClN3O2S
• Molecular Weight: 349.84
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 863029-89-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 597.9°C at 760 mmHg
• Flash Point: 315.4°C
• Appearance: /
• Density: 1.45
• Vapor Pressure: 2.93E-14mmHg at 25°C
• Refractive Index: 1.693
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: (S)-4-Desmethoxy-4-chloro Omeprazole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Desmethoxy-4-chloro Omeprazole(863029-89-4)
• EPA Substance Registry System: (S)-4-Desmethoxy-4-chloro Omeprazole(863029-89-4)

Safety Data

• Hazardous Substances Data: 863029-89-4(Hazardous Substances Data)

Usage

Description

(S)-4-Desmethoxy-4-chloro Omeprazole, also known as Omeprazole EP Impurity H, is a chiral impurity derived from the synthesis of Omeprazole. It is characterized by the absence of a methoxy group and the presence of a chloro group at the 4-position, which distinguishes it from the parent compound. This impurity plays a significant role in the pharmaceutical industry, particularly in the development and quality control of Omeprazole-based medications.

Uses

Used in Pharmaceutical Industry:
(S)-4-Desmethoxy-4-chloro Omeprazole is used as an impurity control agent for the synthesis of Omeprazole. It is essential in ensuring the purity and quality of the final product, as impurities can affect the safety, efficacy, and stability of the medication. By monitoring and controlling the presence of this impurity, pharmaceutical companies can maintain the desired standards for their Omeprazole-based products.
Used in Quality Control and Analysis:
(S)-4-Desmethoxy-4-chloro Omeprazole is utilized as a reference compound in analytical methods for the detection and quantification of impurities in Omeprazole. This helps in the development of accurate and reliable analytical techniques, which are crucial for assessing the quality of pharmaceutical products and ensuring compliance with regulatory standards.
Used in Research and Development:
As an impurity derived from the synthesis of Omeprazole, (S)-4-Desmethoxy-4-chloro Omeprazole serves as a valuable compound in research and development efforts. It can be used to study the effects of impurities on the properties and performance of Omeprazole, as well as to develop new methods for impurity removal or reduction. This contributes to the ongoing improvement of pharmaceutical manufacturing processes and the development of safer and more effective medications.

InChI:InChI=1/C16H16ClN3O2S/c1-9-7-18-14(10(2)15(9)17)8-23(21)16-19-12-5-4-11(22-3)6-13(12)20-16/h4-7H,8H2,1-3H3,(H,19,20)