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86347-15-1

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  • Factory Price API 99% (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride 86347-15-1 GMP Manufacturer

    Cas No: 86347-15-1

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86347-15-1 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 86347-15-1 differently. You can refer to the following data:
1. Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor
2. An α2-Adrenergic agonist. Sedative; analgesic.
3. α2-Adrenergic agonist. Sedative; analgesic.

Biological Activity

medetomidine is a selective α2-adrenoceptor agonist, with ki of 1.08 nm, exhibts 1620-fold selectivity over α1-adrenoceptor.

Check Digit Verification of cas no

The CAS Registry Mumber 86347-15-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,4 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 86347-15:
(7*8)+(6*6)+(5*3)+(4*4)+(3*7)+(2*1)+(1*5)=151
151 % 10 = 1
So 86347-15-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H

86347-15-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name medetomidine hydrochloride

1.2 Other means of identification

Product number -
Other names medetomidine HCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86347-15-1 SDS

86347-15-1Relevant articles and documents

Preparation method of dexmedetomidine hydrochloride intermediate

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Paragraph 0047-0056, (2022/01/20)

The invention provides a preparation method of a dexmedetomidine intermediate. The method comprises the following steps: (1) dissolving Lewis acid in an aprotic organic solvent, cooling to below 10 DEG C, dropwise adding N-Boc-imidazole dissolved in an aprotic organic solvent, controlling the temperature below 10 DEG C, and uniformly mixing; (2) dropwise adding 1-(1-chloroethyl)-2, 3-dimethyl benzene, heating to 0-45 DEG C after dropwise adding until the reaction is complete, adding water or an inorganic acid aqueous solution for quenching, adding an aprotic organic solvent for extraction, and collecting and merging an extracted organic layer; and (3) adding a poor solvent into the organic layer, separating out a product, and drying. According to the preparation method, by optimizing the feed ratio and reaction conditions, side reactions and by-products are remarkably reduced, the production cost is remarkably reduced, the yield is high, the process is stable, and the preparation method is suitable for industrial mass production.

NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES

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, (2013/03/26)

There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.

Method for preparing medetomidine and its salts

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Page/Page column 6, (2008/12/04)

The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.

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