86347-15-1Relevant articles and documents
Preparation method of dexmedetomidine hydrochloride intermediate
-
Paragraph 0047-0056, (2022/01/20)
The invention provides a preparation method of a dexmedetomidine intermediate. The method comprises the following steps: (1) dissolving Lewis acid in an aprotic organic solvent, cooling to below 10 DEG C, dropwise adding N-Boc-imidazole dissolved in an aprotic organic solvent, controlling the temperature below 10 DEG C, and uniformly mixing; (2) dropwise adding 1-(1-chloroethyl)-2, 3-dimethyl benzene, heating to 0-45 DEG C after dropwise adding until the reaction is complete, adding water or an inorganic acid aqueous solution for quenching, adding an aprotic organic solvent for extraction, and collecting and merging an extracted organic layer; and (3) adding a poor solvent into the organic layer, separating out a product, and drying. According to the preparation method, by optimizing the feed ratio and reaction conditions, side reactions and by-products are remarkably reduced, the production cost is remarkably reduced, the yield is high, the process is stable, and the preparation method is suitable for industrial mass production.
NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES
-
, (2013/03/26)
There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
Method for preparing medetomidine and its salts
-
Page/Page column 6, (2008/12/04)
The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.