863588-32-3

Basic information

• Product Name: ML-180
• Synonyms: ML-180;6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione
• CAS NO: 863588-32-3
• Molecular Formula: C20H25ClN4O2
• Molecular Weight: 388.8911
• Mol File: 863588-32-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.312±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.37±0.40(Predicted)
• CAS DataBase Reference: ML-180(CAS DataBase Reference)
• NIST Chemistry Reference: ML-180(863588-32-3)
• EPA Substance Registry System: ML-180(863588-32-3)

Safety Data

• Hazardous Substances Data: 863588-32-3(Hazardous Substances Data)

Usage

Description

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1) with an IC50 of 3.7 μM and a maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. ML-180 modulates the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).

Uses

Used in Pharmaceutical Industry:
ML-180 is used as a therapeutic agent for the treatment of breast cancer, specifically targeting estrogen-receptor negative MDA-MB-231 breast cancer cells. Its mechanism of action involves modulating the expression of haptoglobin and serum amyloid proteins A1 and A4, as well as inhibiting the steroidogenic acute regulatory promoter.
Used in Drug Development:
ML-180 is used as a research tool for studying the role of liver receptor homolog-1 (LRH-1) in various biological processes and its potential as a target for drug development. Its inverse agonist activity and specificity for LRH-1 make it a valuable compound for investigating the therapeutic potential of modulating LRH-1 activity in different diseases and conditions.