863910-65-0

Basic information

• Product Name: C₁₇H₁₇F₃N₄O₄
• Synonyms: C₁₇H₁₇F₃N₄O₄
• CAS NO: 863910-65-0
• Molecular Weight: 398.342
• Mol File: 863910-65-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₇F₃N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₇F₃N₄O₄(863910-65-0)
• EPA Substance Registry System: C₁₇H₁₇F₃N₄O₄(863910-65-0)

Safety Data

• Hazardous Substances Data: 863910-65-0(Hazardous Substances Data)

Upstream product

• 87128-15-2 4-<2-(acetamido)ethyl>-2-nitro-acetanilide 
• 159417-92-2 4-<2-(acetamido)ethyl>-acetanilide 
• 6270-07-1 N-<2-(4-nitrophenyl)ethyl>acetamide 
• 40377-41-1 4-(2-(((methyl)carbonyl)amino)ethyl)aniline 
• 16588-75-3 2-methoxy-5-trifluoromethylphenyl isocyanate 
• 159417-93-3 4-(2-aminoethyl)-2-nitro-phenylamine 
• 349-65-5 2-Methoxy-5-trifluoromethyl-aniline 

Downstream Products

• 863910-71-8 C₁₉H₁₆Cl₃F₃N₄O₂ 
• 863910-69-4 C₁₈H₁₈F₃N₅O₂ 
• 863910-59-2 C₂₀H₂₀F₃N₅O₄ 

Relevant articles and documents

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors

RAF kinase plays a critical role in the RAF-MEK-ERK signaling pathway and inhibitors of RAF could be of use for the treatment of various cancer types. We have designed potent RAF-1 inhibitors bearing novel bicyclic heterocycles as key structural elements for the interaction with the hinge region. In both series exploration of the SAR was focussed on the substitution of the phenyl ring, which binds to the induced fit pocket. Overall, it was confirmed that incorporation of lipophilic substituents was needed for potent Raf inhibition and a number of potent analogues were obtained.