86401-80-1

Basic information

• Product Name: 16alpha-Hydroxyprednisonlone acetate
• Synonyms: 16A-HYDROXY-PREDNISONLONE ACETATE;16alpha-hydroxyprednisonlone acetate;11b,16a,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 21-acetate;16ALPHA-HYDROXYPRENISOLONEACETATE;16α-HYDROXY-PREDNISONLONEACETATE;16alpha-Hydroxy-prednisolone acetate;11b,16a,17 a,21-tetrahydroxylpregn-1,4diene-3,20-dione-21-acetate;16α-Hydroxyprednisolone acetate
• CAS NO: 86401-80-1
• Molecular Formula: C₂₃H₃₀O₇
• Molecular Weight: 418.48
• EINECS: 2017-001-1
• Product Categories: Pharmaceutical Raw Materials;Pharmaceutical Intermediates
• Mol File: 86401-80-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 593.3oC at 760 mmHg
• Flash Point: 202.5oC
• Appearance: /
• Density: 1.34
• Vapor Pressure: 6.35E-15mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: 2-8°C
• PKA: 11.88±0.70(Predicted)
• CAS DataBase Reference: 16alpha-Hydroxyprednisonlone acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 16alpha-Hydroxyprednisonlone acetate(86401-80-1)
• EPA Substance Registry System: 16alpha-Hydroxyprednisonlone acetate(86401-80-1)

Safety Data

• Hazardous Substances Data: 86401-80-1(Hazardous Substances Data)

Usage

用途

16α-Hydroxyprednisolone Acetate is used to observe interaction of some steroid drugs with β-cyclodextrin polymer to calculate the relative strengh of interaction between the hydrophobicity parameters of the drugs and the strenght of the drug-β-?cyclodextrin polymer.

Uses

16α-Hydroxyprednisolone Acetate is used to observe interaction of some steroid drugs with β-cyclodextrin polymer to calculate the relative strengh of interaction between the hydrophobicity parameters of the drugs and the strenght of the drug-β-?cyclodextrin polymer.

InChI:InChI=1/C23H30O7/c1-11-5-6-16-21(2,3)19(27)15(26)9-22(16,4)23(11)8-13-14(25)7-12(10-24)17(20(28)29)18(13)30-23/h7,10-11,15-16,19,25-27H,5-6,8-9H2,1-4H3,(H,28,29)/t11-,15-,16?,19-,22+,23-/m1/s1

Upstream product

• 3044-42-6 21-acetoxy-11β-hydroxyl-1,4,16-pregnatriene-3,20-dione 
• 37413-91-5 2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 51333-05-2 (S)-budesonide acetate 
• 77017-20-0 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 13951-70-7 desonide 
• 108-24-7 acetic anhydride 
• 91160-89-3 9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate 
• 10025-73-7 chromium(III) chloride 
• 7440-47-3 chromium 

Downstream Products

• 126544-47-6 ciclesonide 
• 161115-59-9 desisobutyryl ciclesonide 
• 51372-28-2 (22S)-Budesonide 
• 638-94-8 desonide 
• 4533-89-5 21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione 
• 3385-03-3 flunisolide 
• 13951-70-7 desonide 
• 51333-05-2 (R)-budesonide acetate 
• 51333-05-2 2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate 

Relevant articles and documents

Preparation method of glucocorticoid key intermediate

The invention provides a preparation method of a compound (III), which comprises the following steps: in an organic solvent, in the presence of a phase inversion catalyst and an organic acid, controlling the pH value of a reaction system to be 2-6, and oxidizing a compound (II) by potassium permanganate to obtain the compound (III). The invention also provides application of the preparation methodin preparation of budesonide.

A budesonide industrial preparation method (by machine translation)

The invention relates to a cloth budesonide industrial preparation method. Specifically, the invention relates to a hydrochloric acid aqueous solution, dichloromethane and in acetonitrile, 16 α - hydroxy prednisolone with butyraldehyde by the reaction of the budesonide. In the method of the present invention has the industrial can be implemented on, repeatability and the like. (by machine translation)

Preparation method of 16a-prednisolone hydroxyacetate

Disclosed is a preparation method of 16a-prednisolone hydroxyacetate. The method comprises dissolving 17-prednison dehydroxylated acetate as the raw material into organic solvent, under catalysis of acids, oxidizing 16th and 17th double bonds through potassium permanganate to obtain an oxide, and dissolving the oxide into acetone for acid-catalyzed reaction to obtain a protector; dissolving the protector into organic solvent, adding in reducing agent to reduce 11th ketone, then directly adding in acid aqueous solution for hydrolysis and deprotection to obtain the 16a-prednisolone hydroxyacetate. Although the preparation method of the 16a-prednisolone hydroxyacetate adds the two reaction steps of protection and deprotection, every unit reaction is high in yield, the third and fourth reaction steps can be completed within on pot, so that the production operation can be simple and convenient, the production processes are economical and environmentally friendly, the problems of many side reactions and impurities and difficulty impurity refining of oxidation reaction in traditional production process can be greatly solved, the total synthesizing yield can be greatly increased, and compared with traditional production methods, the preparation method of the 16a-prednisolone hydroxyacetate can reduce the production cost by 20-25%.