86499-24-3

Basic information

• Product Name: 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
• Synonyms: 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE;3-azido-2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine;2H-1-Benzazepin-2-one, 3-azido-1,3,4,5-tetrahydro-;3-azido-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
• CAS NO: 86499-24-3
• Molecular Formula: C10H10N4O
• Molecular Weight: 0
• Mol File: 86499-24-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 150-151 °C
• Appearance: /
• CAS DataBase Reference: 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE(86499-24-3)
• EPA Substance Registry System: 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE(86499-24-3)

Safety Data

• Hazardous Substances Data: 86499-24-3(Hazardous Substances Data)

Usage

General Description

3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE is a chemical compound that belongs to the class of benzazepine derivatives. It contains an azido group and is a tetrahydro-2H-1-benzazepin-2-one derivative. 3-AZIDO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE is a potential intermediate in the synthesis of pharmaceutical drugs and other organic compounds. It has the potential to be used in medicinal chemistry for the development of new drugs due to its unique structure and properties. However, it is important to handle this compound with care due to its potentially reactive nature.

InChI:InChI=1/C10H10N4O/c11-14-13-9-6-5-7-3-1-2-4-8(7)12-10(9)15/h1-4,9H,5-6H2,(H,12,15)

Upstream product

• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 86499-96-9 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 86499-22-1 3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 140700-64-7 3-iodo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 86499-23-2 3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 

Downstream Products

• 1093980-71-2 (R)-3-{4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,2,3-triazol-1-yl}-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 1093975-42-8 (S)-3-{4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,2,3-triazol-1-yl}-1,3,4,5-tetrahydro-1-benzazepin-2-one 

Relevant articles and documents

Modular click chemistry libraries for functional screens using a diazotizing reagent

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties1. Copper(i)-catalysed azide–alkyne cycloaddition (CuAAC) triazole annulation and sulfur(vi) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions2–4, providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups5. The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide6–11 (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS

A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.