865-43-0Relevant articles and documents
The dipole gradient for isolated C-H stretches 2. Partially deuterated methyl fluoride, methyl chloride and methyl iodide
Grupping, A. Y.,McKean, D. C.,Veken, B. J. van der
, p. 313 - 324 (1993)
The vapour phase infrared contours, at 0.5 cm-1 resolution, of the C-H stretch fundamental in CHD2F, CHD2Cl and CHD2I have been simulated using anharmonic rigid asymmetric top calculations.The smallest angle between the C-H bond direction and the dipole gradient that reproduces the experimental contour, obtained by rotating the gradient from the C-H bond towards the bisector of the methyl group, was found to be 15 +/- 5 deg in CHD2F, 38 +/- 2 deg in CHD2Cl and 49 +/- 3 deg in CHD2I.Together with the corresponding value for CHD2Br, these results are compared with the polarizability of the halogen atom.
Isothermal pyrolysis of iodomethanes in gases
Skorobogatov,Khripun,Rebrova
scheme or table, p. 2641 - 2651 (2010/06/14)
The fact was established that the pyrolysis of gaseous iodomethanes RI yields methane and non traces of recombination products R2. A pyrolysis mechanism was proposed and rate constants of limiting stages of the pyrolysis of iodomethane, trideuteroiodomethane, and diiodomethane over the range of 500-1500 K were determined. Pleiades Publishing, Ltd., 2009.
Regiospecificity and Isotope Effects Associated with the Methyl-Methylene Eliminations in the Enzyme-Catalyzed Biosynthesis of (R)- and (S)-Limonene
Pyun, Hyung-Jung,Coates, Robert M.,Wagschal, Kurt C.,McGeady, Paul,Croteau, Rodney B.
, p. 3998 - 4009 (2007/10/02)
-, -, and geranyldiphosphates (1-t, 1-d4, and 1-d6,t) were synthesized and used as substrates for several monoterpene cyclases to determine the regiospecificity and isotope effects attending the terminating proton transfers in the enzyme-catalyzed biosynthesis of (R)- and (S)-limonene.Degradation of enantiomeric limonenes produced by cyclization of 1-t with the (+)- and (-)-pinene cyclases (synthases) from Salvia officinalis demonstrated that the eliminations occur at both the cis- (55-65percent) and trans-methyl (45-35percent) groups.In contrast, the terminating eliminations in the formation of (+)- and (-)-limonene catalyzed by limonene cyclases from Citrus sinensis and Perilla frutescens, respectively, were shown by degradation to occur exclusively (>/=97-98percent) at the cis terminal methyl group.The intramolecular isotope effects for the methyl-methylene elimination in limonene biosynthesis catalyzed by (+)- and (-)-pinene cyclases from S. officinalis were found to be kH/kD = 2.3 +/- 0.2 and 5.9 +/- 0.5, respectively, by GC/MS determinations of -limonene derived from enzymatic cyclizations of 1-d4.Similar experiments with (-)-limonene cyclase from Mentha spicata resulted in kH/kD = 4.0 +/- 0.4.Incubations of 1-d6,t with pinene and bornyl PP cyclases from S. officinalis exhibited significant remote isotope effects (kH/kD = 1.16-1.27) on the total rate of monoterpene formation which suggest that the initial cyclization step of the enzyme-bound linalyl diphosphate intermediate is an important component of the overall rate of the enzymatic reactions.The isotope effects on the partitioning of the α-terpinyl carbocation intermediate between bicyclization and elimination to limonene were determined from the effects of deuterium substitution on the product ratios derived from enzymatic cyclization of 1-d6,t.The small size of these product isotope effects (kH/kD = 1.2-1.7) is attributed to a conformational inversion of the α-terpinyl ion to a half-chair conformer prior to proton elimination to limonene, thereby rendering the bicyclizations relatively immune to the intrinsic deuterium isotope effect.The regiospecific proton transfers from the cis terminal methyl group effected by the limonene cyclases from Citrus and Perilla are attributed to the minimization of charge seperation in the transition state.
