865622-29-3Relevant articles and documents
Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity
Ortmann, Regina,Wiesner, Jochen,Reichenberg, Armin,Henschker, Dajana,Beck, Ewald,Jomaa, Hassan,Schlitzer, Martin
, p. 305 - 314 (2007/10/03)
FR900098 represents a derivative of the new antimalarial drug fosmidomycin with enhanced activity. The mechanism of action is the inhibition of the 1-desoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase, an essential enzyme of the mevalonate independent