865670-11-7

Basic information

• Product Name: 7-(3,5-difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one
• Synonyms: 7-(3,5-difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one
• CAS NO: 865670-11-7
• Molecular Weight: 303.308
• Mol File: 865670-11-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(3,5-difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3,5-difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one(865670-11-7)
• EPA Substance Registry System: 7-(3,5-difluorophenyl)-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one(865670-11-7)

Safety Data

• Hazardous Substances Data: 865670-11-7(Hazardous Substances Data)

Upstream product

• 865670-74-2 7-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one 
• 156545-07-2 3,5-difluorophenylboronic acid 

Relevant articles and documents

7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists

Novel 7-aryl benzo[1,4]oxazepin-2-ones were synthesized and evaluated as non-steroidal progesterone receptor (PR) modulators. The structure activity relationship of 7-aryl benzo[1,4]oxazepinones was examined using the T47D cell alkaline phosphatase assay. A number of 7-aryl benzo[1,4]oxazepinones such as 10j and 10v demonstrated good in vitro potency (IC50 of 10-30 nM) and selectivity (over 100-fold) at PR over other steroidal receptors such as glucocorticoid and androgen receptors (GR and AR). Several 7-aryl benzo[1,4]oxazepinones were active in the rat uterine decidualization model. In this in vivo model, compounds 10j and 10u were active at 3 mg/kg when dosed orally.