86604-68-4 Usage
General Description
The chemical 2-[(4-Methoxy-3-methylpyridinyl)methylsulfinyl]-5-trifluoromethylbenzimidazole is a benzimidazole derivative that is used as a proton pump inhibitor. It works by inhibiting the production of stomach acid, making it effective in treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers. This chemical is often marketed under the brand name rabeprazole and is typically available in tablet or capsule form for oral administration. Its chemical structure contains a benzimidazole core with a trifluoromethyl group and a substituted pyridinylmethylsulfinyl group, making it a potent and specific inhibitor of acid secretion in the stomach.
Check Digit Verification of cas no
The CAS Registry Mumber 86604-68-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,6,0 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 86604-68:
(7*8)+(6*6)+(5*6)+(4*0)+(3*4)+(2*6)+(1*8)=154
154 % 10 = 4
So 86604-68-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H14F3N3O2S/c1-9-13(20-6-5-14(9)24-2)8-25(23)15-21-11-4-3-10(16(17,18)19)7-12(11)22-15/h3-7H,8H2,1-2H3,(H,21,22)
86604-68-4Relevant articles and documents
Activation of chloride channels for correction of defective chloride transport
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, (2008/06/13)
This invention provides a method for increasing the permeability of epithelial cells to a chloride ion in a subject comprising administering a permeability enhancing amount of a composition comprising a specifically-defined nontoxic, benzimidazole or benzimidazole derivative. The invention also relates to a method of treating cystic fibrosis comprising administering an epithelial cell chloride permeability enhancing amount of a composition comprising a specifically-defined nontoxic, benzimidazole or benzimidazole derivative. The benzimidazole compound having chloride channel activation activity for use in this invention includes a 2-[(pyridyl)-methylsulfinyl or -methylthio]benzimidazole derivatives and salts thereof, for instance. Specifically, these include the compounds omeprazole, lansoprazole, thimoprazole and pantoprazole. When appropriately applied, these compounds can correct detective chloride transport, increasing the salt and water flux in diseased tissues to levels closer to those of normal tissues thus reducing life-threatening complications.
