866458-10-8

Basic information

• Product Name: 3-(2,4,6-trimethylphenyl)prop-2-en-1-ol
• Synonyms: 3-(2,4,6-trimethylphenyl)prop-2-en-1-ol
• CAS NO: 866458-10-8
• Molecular Weight: 176.258
• Mol File: 866458-10-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2,4,6-trimethylphenyl)prop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4,6-trimethylphenyl)prop-2-en-1-ol(866458-10-8)
• EPA Substance Registry System: 3-(2,4,6-trimethylphenyl)prop-2-en-1-ol(866458-10-8)

Safety Data

• Hazardous Substances Data: 866458-10-8(Hazardous Substances Data)

Upstream product

• 487-68-3 mesytaldehyde 
• 84001-90-1 (E)-ethyl 3-mesitylacrylate 
• 1052201-89-4 (E)-2-(3-chloroprop-1-enyl)-1,3,5-trimethylbenzene 

Downstream Products

• 1213370-88-7 (S)-1-(2,4,6-trimethylphenyl)-prop-2-en-1-amine 
• 1332888-00-2 2,2,2-trichloro-N-[1-(2,4,6-trimethylphenyl)allyl]acetamide 

Relevant articles and documents

Highly Enantioselective Synthesis of Functionalized Glutarimide Using Oxidative N-Heterocyclic Carbene Catalysis: A Formal Synthesis of (?)-Paroxetine

A simple yet highly effective approach toward enantioselective synthesis of trans-3,4-disubstituted glutarimides from readily available starting materials is developed using oxidative N-heterocyclic carbene catalysis. The catalytic reaction involves a formal [3 + 3] annulation between enals and substituted malonamides enabling the production of glutarimide derivatives in a single chemical operation via concomitant formation of C-C and C-N bonds. The reaction offers easy access to a broad range of functionalized glutarimides with excellent enantioselectivity and good yield. Synthetic application of the method is demonstrated via formal synthesis of (?)-paroxetine and other bioactive molecules.

Ruthenium-catalyzed synthesis of allylic alcohols: Boronic acid as a hydroxide source

Secondary allylic alcohols were synthesized from linear allylic halides or carbonates using a catalytic amount of a ruthenium complex in the presence of boronic acid. The effects of solvent, base, ruthenium precursor, and boronic acid were fully explored, and the scope of the reaction was extended to various sub-strates. We also describe a preliminary investigation towards an enantioselective process.