866837-96-9

Basic information

• Product Name: Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate
• Synonyms: ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate;5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS NO: 866837-96-9
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25
• Product Categories: Pyrazole
• Mol File: 866837-96-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 413 °C at 760 mmHg
• Flash Point: 203.6 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 4.96E-07mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate(866837-96-9)
• EPA Substance Registry System: Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate(866837-96-9)

Safety Data

• Hazardous Substances Data: 866837-96-9(Hazardous Substances Data)

Usage

General Description

Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate is a chemical compound with the molecular formula C12H12N4O2. It is a pyrazole derivative that is commonly used in the pharmaceutical industry for the synthesis of various drugs and bioactive molecules. Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate has shown potential anti-inflammatory, analgesic, and antipyretic properties in experimental studies. It is also used in the development of new chemical entities for potential therapeutic applications. Additionally, it is used as a building block in organic chemistry for the synthesis of more complex molecules and can serve as a valuable intermediate in the production of pharmaceuticals and agrochemicals.

InChI:InChI=1/C12H13N3O2/c1-2-17-12(16)10-8-11(13)15(14-10)9-6-4-3-5-7-9/h3-8H,2,13H2,1H3

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 64-17-5 ethanol 
• 92664-05-6 potassium 1-cyano-3-ethoxy-3-oxoprop-1-en-2-olate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 866838-11-1 1-phenyl-5-[3-benzoyl-thioureido]-1H-pyrazole-3-carboxylic acid ethyl ester 
• 1015765-50-0 C₁₆H₁₅N₃O₂ 
• 1391944-38-9 5-(2,2-Dimethyl-propionylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 1053164-76-3 5-amino-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 1391943-01-3 (S)-3-[(5-amino-1-phenyl-1H-pyrazole-3-carbonyl)amino]-3-(o-tolyl)propionic acid 
• 1279037-47-6 (S)-3-{[5-((cyclopropylmethyl)amino)-1-phenyl-1H-pyrazole-3-carbonyl]amino}-3-(o-tolyl)propionic acid 
• 1279037-44-3 (S)-3-{[5-(bis-(cyclopropylmethyl)-amino)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid 
• 1391944-27-6 1-phenyl-5-pyrrolidin-1-yl-1H-pyrazole-3-carboxylic acid 
• 1391944-30-1 1-Phenyl-5-(3-phenyl-ureido)-1H-pyrazole-3-carboxylic acid 
• 1391944-32-3 5-methanesulfonylamino-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 1391944-34-5 5-(2-oxo-pyrrolidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 1391944-36-7 1-phenyl-5-(pyridin-2-ylamino)-1H-pyrazole-3-carboxylic acid 
• 1391944-57-2 5-((cyclopropylmethyl)amino)-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 1391944-59-4 5-(bis-(cyclopropyl-methyl)-amino)-1-phenyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Diazole-pyrazolecarboxamide derivative and microwave hydrothermal synthesis method and application thereof

The invention relates to the technical field of organic synthesis, in particular to a N-(5-[1,3,4]diazole-2-yl-2H-pyrazole-3-yl)-carboxamide derivative and a microwave hydrothermal synthesis method thereof, and further relates to application of the compound. A series of basic raw materials such as amine, 2,3-dicyan-opropionate, alcohol, acyl halide and the like are used for synthetizing of pyrazolecarbonitrile, pyrazolecarbonitrile is subjected to esterification, hydrazide reaction and amidation and reacts with a cyclization agent by the microwave hydrothermal synthesis method so as to obtainN-(5-[1,3,4]diazole-2-yl-2H-pyrazole-3-yl)-carboxamide derivative (including thiadiazole and oxadiazole). The derivative has good biological activity, can inhibit various bacterial stains, and has high activity in terms of bacterial resistance and insect killing; in terms of chemical structure, the derivative, according with the general formula, is synthetized, has great variety of active groups and excellent photo-physical properties, has multiple functions in the fields such as photoelectricity, medicines, pesticides, bacteriostat, diminish inflammation and virus protection, and accordinglyhas high development and application value.

TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF

The present invention is directed to substituted five membered heteroaryl benzamide compounds compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula (I), wherein A, D, E, G, R10 R11, R30 R40 R50