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867-13-0

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867-13-0 Usage

Chemical Properties

Triethyl phosphonoacetate is Colorless to light yellow liqui

Uses

Different sources of media describe the Uses of 867-13-0 differently. You can refer to the following data:
1. Triethyl phosphonoacetate is used for Horner-Emmons modification.
2. Triethyl phosphonoacetate serves as a reactant used in Horner-Wadsworth-Emmons reactions, Tsuji-Trost type reactions, Intramolecular Heck-type cyclization and isomerizations and Intramolecular aryne-ene reactions. In Horner-Wadsworth-Emmons reaction, it is utilized as a reagent to prepare chiral 2-methylcyclopropanecarboxylic acid from (S)-propylene oxide.

Purification Methods

Purify it by fractional distillation, preferably in vacuo. NMR has P resonance at 19.5 relative to orthophosphate. [Kosolapoff & Powell J Am Chem Soc 68 1103 1946, Kosolapoff & Powell J Am Chem Soc 72 4198 1950, Speziale & Freeman J Org Chem 23 1586 1958, Beilstein 4 IV 3613.]

Check Digit Verification of cas no

The CAS Registry Mumber 867-13-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,6 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 867-13:
(5*8)+(4*6)+(3*7)+(2*1)+(1*3)=90
90 % 10 = 0
So 867-13-0 is a valid CAS Registry Number.

867-13-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D1523)  Triethyl Phosphonoacetate  >97.0%(GC)

  • 867-13-0

  • 25g

  • 90.00CNY

  • Detail
  • TCI America

  • (D1523)  Triethyl Phosphonoacetate  >97.0%(GC)

  • 867-13-0

  • 100g

  • 390.00CNY

  • Detail
  • TCI America

  • (D1523)  Triethyl Phosphonoacetate  >97.0%(GC)

  • 867-13-0

  • 500g

  • 800.00CNY

  • Detail
  • Alfa Aesar

  • (A14120)  Triethyl phosphonoacetate, 98+%   

  • 867-13-0

  • 100g

  • 120.0CNY

  • Detail
  • Alfa Aesar

  • (A14120)  Triethyl phosphonoacetate, 98+%   

  • 867-13-0

  • 500g

  • 865.0CNY

  • Detail
  • Alfa Aesar

  • (A14120)  Triethyl phosphonoacetate, 98+%   

  • 867-13-0

  • 2500g

  • 4324.0CNY

  • Detail
  • Sigma-Aldrich

  • (79525)  Triethylphosphonoacetate  purum, ≥97.0% (GC)

  • 867-13-0

  • 79525-100ML

  • 1,067.04CNY

  • Detail
  • Sigma-Aldrich

  • (79525)  Triethylphosphonoacetate  purum, ≥97.0% (GC)

  • 867-13-0

  • 79525-500ML

  • 4,036.50CNY

  • Detail
  • Aldrich

  • (T61301)  Triethylphosphonoacetate  98%

  • 867-13-0

  • T61301-25G

  • 366.21CNY

  • Detail
  • Aldrich

  • (T61301)  Triethylphosphonoacetate  98%

  • 867-13-0

  • T61301-100G

  • 945.36CNY

  • Detail

867-13-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Triethyl phosphonoacetate

1.2 Other means of identification

Product number -
Other names Ethyl 2-(diethoxyphosphoryl)acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:867-13-0 SDS

867-13-0Synthetic route

ethyl bromoacetate
105-36-2

ethyl bromoacetate

triethyl phosphite
122-52-1

triethyl phosphite

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
at 60 - 80℃; for 0.5h; Arbusov reaction;100%
at 150℃; for 3h;99%
for 0.0333333h; Michaelis-Arbuzov reaction; microwave irradiation;98%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

triethyl phosphite
122-52-1

triethyl phosphite

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
In toluene at 170℃; under 7500.75 Torr; for 0.333333h; Pressure; Temperature; Arbuzov Reaction; Large scale;95%
at 120 - 165℃; for 2h;93%
for 2h; Inert atmosphere; Reflux;63%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With triethyl phosphite89.3%
triethyl phosphate
78-40-0

triethyl phosphate

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
at 140℃; for 3h;88%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With copper acetylacetonate In benzene Product distribution; Heating; other catalysts, other diazo compounds, other hydrophosphoryl compounds;83%
copper acetylacetonate In benzene for 1h; Heating;83%
With copper acetylacetonate In benzene Heating;83%
With trifluorormethanesulfonic acid In benzene Heating;2%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; 18-crown-6 ether at 80℃; for 6h;77%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 5℃; for 0.333333h;55%
With potassium carbonate In ethanol at 78℃; for 2h; Substitution; Michaelis-Becker reaction;33%
methyl vinyl ketone
78-94-4

methyl vinyl ketone

diethyl 1-iodo-1-carbethoxy-methylphosphonate
66700-63-8

diethyl 1-iodo-1-carbethoxy-methylphosphonate

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

2-(Diethoxy-phosphoryl)-5-oxo-hexanoic acid ethyl ester

2-(Diethoxy-phosphoryl)-5-oxo-hexanoic acid ethyl ester

Conditions
ConditionsYield
With triethyl borane; tri-n-butyl-tin hydride In hexane; toluene at -78℃; for 6h; Yields of byproduct given;A n/a
B 77%
Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

XC(O)OC2H5

XC(O)OC2H5

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With n-butyllithium; lithium diisopropyl amide In tetrahydrofuran; hexane at -60℃;74%
2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde
132646-34-5

2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

ethyl (E)-3-[2-(5-methyl-2-phenyl-4-oxazolylmethyl)benzofuran-5-yl]acrylate
159017-57-9

ethyl (E)-3-[2-(5-methyl-2-phenyl-4-oxazolylmethyl)benzofuran-5-yl]acrylate

Conditions
ConditionsYield
A n/a
B 74%
Methyl diethylphosphonoacetate
1067-74-9

Methyl diethylphosphonoacetate

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-oxo-1H-pyrrolo-<2,3-d>carbazole-6-carboxylate
219650-29-0

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-oxo-1H-pyrrolo-<2,3-d>carbazole-6-carboxylate

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-(E)-<(methoxycarbonyl)methylene>-1H-pyrrolo<2,3-d>carbazole-6-carboxylates
219650-31-4

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-(E)-<(methoxycarbonyl)methylene>-1H-pyrrolo<2,3-d>carbazole-6-carboxylates

C

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-(Z)-<(methoxycarbonyl)methylene>-1H-pyrrolo<2,3-d>carbazole-6-carboxylates
219650-30-3

(-)-methyl (2S,3aS,5R,11bR)-3-benzyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-12-(Z)-<(methoxycarbonyl)methylene>-1H-pyrrolo<2,3-d>carbazole-6-carboxylates

Conditions
ConditionsYield
With potassium hexamethyldisilazane In tetrahydrofuran for 0.5h; Ambient temperature; Yield given;A n/a
B 64%
C n/a
Diethyl phosphonate
762-04-9, 123-22-8

Diethyl phosphonate

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With sodium In diethyl ether60%
(E)-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]cinnamaldehyde
159017-37-5

(E)-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]cinnamaldehyde

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

ethyl (E)-5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]-2,4-pentadienoate
1026936-75-3

ethyl (E)-5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]-2,4-pentadienoate

Conditions
ConditionsYield
A n/a
B 56%
vinyl acetate
108-05-4

vinyl acetate

diethyl 1-iodo-1-carbethoxy-methylphosphonate
66700-63-8

diethyl 1-iodo-1-carbethoxy-methylphosphonate

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

4-Acetoxy-2-(diethoxy-phosphoryl)-butyric acid ethyl ester

4-Acetoxy-2-(diethoxy-phosphoryl)-butyric acid ethyl ester

Conditions
ConditionsYield
With triethyl borane; tri-n-butyl-tin hydride In hexane; toluene at -78℃; for 6h; Yields of byproduct given;A n/a
B 38%
triethyl 2-chloro-2-phosphonoacetate
7071-12-7

triethyl 2-chloro-2-phosphonoacetate

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

(E)-ethyl 2-chloro-3-(4-methoxyphenyl)propenoate
66051-39-6

(E)-ethyl 2-chloro-3-(4-methoxyphenyl)propenoate

C

(E)-methoxyphenyl-3 chloro-2 propenoate d'ethyle
66051-40-9

(E)-methoxyphenyl-3 chloro-2 propenoate d'ethyle

Conditions
ConditionsYield
With tetramethylammonium tetrafluoroborate; 4-methoxy-benzaldehyde In N,N-dimethyl-formamide Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag; Yields of byproduct given;A 22%
B n/a
C n/a
triethyl 2-chloro-2-phosphonoacetate
7071-12-7

triethyl 2-chloro-2-phosphonoacetate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

(E)-ethyl 2-chloro-3-(4-methoxyphenyl)propenoate
66051-39-6

(E)-ethyl 2-chloro-3-(4-methoxyphenyl)propenoate

C

(E)-methoxyphenyl-3 chloro-2 propenoate d'ethyle
66051-40-9

(E)-methoxyphenyl-3 chloro-2 propenoate d'ethyle

Conditions
ConditionsYield
With tetramethylammonium tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag; Yield given;A 22%
B n/a
C n/a
triethyl 2-chloro-2-phosphonoacetate
7071-12-7

triethyl 2-chloro-2-phosphonoacetate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
24393-56-4

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

C

(Z)-ethyl 3-(4-methoxyphenyl)acrylate
51507-22-3

(Z)-ethyl 3-(4-methoxyphenyl)acrylate

Conditions
ConditionsYield
With tetramethylammonium tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag; Yield given;A 14%
B n/a
C n/a
diethyl ether
60-29-7

diethyl ether

sodium diethyl phosphite
2303-76-6, 118080-94-7

sodium diethyl phosphite

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

sodium diethyl phosphite
2303-76-6, 118080-94-7

sodium diethyl phosphite

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With hexane
With ligroine
With ethanol
sodium diethyl phosphite
2303-76-6, 118080-94-7

sodium diethyl phosphite

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

benzene
71-43-2

benzene

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

sodium diethyl phosphite
2303-76-6, 118080-94-7

sodium diethyl phosphite

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With benzene
ethanol
64-17-5

ethanol

dichlorophosphoryl-acetyl chloride
34164-06-2

dichlorophosphoryl-acetyl chloride

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With pyridine In diethyl ether
diethyl ester of 2,2-diethoxyethenephosphonic acid
34159-39-2

diethyl ester of 2,2-diethoxyethenephosphonic acid

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid; water
2-Diethoxyphosphoryl-3-dimethylaminoacrylsaeure-ethylester
74119-48-5

2-Diethoxyphosphoryl-3-dimethylaminoacrylsaeure-ethylester

A

benzoimidazole
51-17-2

benzoimidazole

B

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With 1,2-diamino-benzene In ethanol Heating;
diethyl phosphorylchloridite
589-57-1

diethyl phosphorylchloridite

ethyl acetate
141-78-6

ethyl acetate

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
Yield given. Multistep reaction. Further byproducts given;
Diazoethan
1117-96-0

Diazoethan

carbon dioxide
124-38-9

carbon dioxide

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

methyl iodide
74-88-4

methyl iodide

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
In diethyl ether at 0℃; for 0.5h;
2-Diethoxyphosphoryl-3-dimethylaminoacrylsaeure-ethylester
74119-48-5

2-Diethoxyphosphoryl-3-dimethylaminoacrylsaeure-ethylester

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

A

benzoimidazole
51-17-2

benzoimidazole

B

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
In ethanol Heating;
Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

Diethyl carbonate
105-58-8

Diethyl carbonate

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine 1.) hexane, THF, -78 deg C, 5 min, 2.) THF, -78 deg C --> 0 deg C; Yield given. Multistep reaction;
With n-butyllithium 1.) THF, hexane, -55 deg C, 20 min, 2.) THF, hexane, -55 deg C, 30 min; Yield given. Multistep reaction;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

triethyl phosphite
122-52-1

triethyl phosphite

A

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

B

phosphoric acid 1-ethoxy-vinyl ester diethyl ester
63720-98-9

phosphoric acid 1-ethoxy-vinyl ester diethyl ester

Conditions
ConditionsYield
In benzene for 8h; Heating;
In benzene for 8h; Heating;
ethyl 2,2-dichloro-2-diethoxyphosphorylacetate
5823-12-1

ethyl 2,2-dichloro-2-diethoxyphosphorylacetate

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 7 percent / p-methoxybenzaldehyde, Me4NBF4 / dimethylformamide / Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag
2: 22 percent / Me4NBF4, p-methoxybenzaldehyde / dimethylformamide / Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag
View Scheme
Multi-step reaction with 2 steps
1: 7 percent / p-methoxybenzaldehyde, Me4NBF4 / dimethylformamide / Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag
2: 22 percent / Me4NBF4 / dimethylformamide / Ambient temperature; controlled potential electrolysis; cathode: Hg; electrode ref.: AgI/Ag
View Scheme
formaldehyd
50-00-0

formaldehyd

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl 2-diethoxyphosphinoylacrylate
20345-61-3

ethyl 2-diethoxyphosphinoylacrylate

Conditions
ConditionsYield
Stage #1: formaldehyd; diethoxyphosphoryl-acetic acid ethyl ester With piperidine In methanol at 80℃; for 36h;
Stage #2: With toluene-4-sulfonic acid In toluene for 16h; Dean-Stark; Reflux;
100%
Stage #1: formaldehyd With piperidine In methanol for 0.5h; Heating;
Stage #2: diethoxyphosphoryl-acetic acid ethyl ester In methanol for 70h; Heating;
73%
piperidine In methanol Heating;60%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

cyclohexanone
108-94-1

cyclohexanone

ethyl cyclohexylideneacetate
1552-92-7

ethyl cyclohexylideneacetate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil for 1h;
Stage #2: cyclohexanone In tetrahydrofuran; mineral oil for 18h;
100%
With sodium hydride In tetrahydrofuran for 8h;98%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With 15-crown-5; sodium hydride In tetrahydrofuran; mineral oil at 0℃;
Stage #2: cyclohexanone In tetrahydrofuran; mineral oil at -40 - 20℃;
97%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

heptanal
111-71-7

heptanal

ethyl 2-nonenoate
17463-01-3

ethyl 2-nonenoate

Conditions
ConditionsYield
With triethylamine; magnesium bromide In tetrahydrofuran at 25℃; for 12h;100%
(i) NaH, Et2O, (ii) /BRN= 1560236/; Multistep reaction;
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

4-heptanone
123-19-3

4-heptanone

ethyl 3-propylhex-2-enoate
10297-63-9

ethyl 3-propylhex-2-enoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 20℃;
Stage #2: 4-heptanone at 20℃; for 24h; Reflux;
100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: 4-heptanone In tetrahydrofuran; mineral oil at 20℃; Schlenk technique; Inert atmosphere;
88%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester; 4-heptanone With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.333333h; Inert atmosphere; Schlenk technique;
Stage #2: In tetrahydrofuran; mineral oil for 20h; Reflux;
86%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

diethylphosphonoacetic acid
3095-95-2

diethylphosphonoacetic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃;100%
With water; sodium hydroxide In ethanol at 20℃; Inert atmosphere;97%
With hydrogenchloride; potassium hydroxide 1.) aq. EtOH, 20 h;95%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

pivalaldehyde
630-19-3

pivalaldehyde

3-tert-butyl-acrylic acid ethyl ester
87995-20-8

3-tert-butyl-acrylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran Cooling with ice;
Stage #2: pivalaldehyde In tetrahydrofuran at 20℃; for 48h;
Stage #3: With ammonium chloride In tetrahydrofuran; water
100%
(i) NaH, Et2O, (ii) /BRN= 506060/; Multistep reaction;
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; Inert atmosphere;
Stage #2: pivalaldehyde In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
With sodium tert-pentoxide at 0 - 20℃; for 1h; Horner-Wadsworth-Emmons Olefination; Green chemistry;
With sodium hydride In tetrahydrofuran at 0℃; Inert atmosphere;
furfural
98-01-1

furfural

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl (E)-3-(2-furyl)prop-2-enoate
623-20-1

ethyl (E)-3-(2-furyl)prop-2-enoate

Conditions
ConditionsYield
With potassium carbonate In neat (no solvent) Mechanism; var. other bases, effect of water;100%
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h;100%
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h; Product distribution; other catalyst, other solvents, influence of water;100%
3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(E)-3-thiophen-3-yl-acrylic acid ethyl ester
50266-60-9

(E)-3-thiophen-3-yl-acrylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h;
Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran; mineral oil at 20℃; for 1h;
100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃; for 3.25h;
100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate In tetrahydrofuran at 20℃;
Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran at 90℃; for 0.5h;
90%
Tetrahydro-4H-pyran-4-one
29943-42-8

Tetrahydro-4H-pyran-4-one

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl tetrahydro-4H-pyran-4-ylideneacetate
130312-00-4

ethyl tetrahydro-4H-pyran-4-ylideneacetate

Conditions
ConditionsYield
With sodium hydride In mineral oil; benzene at 0 - 20℃; for 2.33333h; Inert atmosphere;100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: Tetrahydro-4H-pyran-4-one In tetrahydrofuran; mineral oil at 20℃; Schlenk technique; Inert atmosphere;
100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;96%
cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate
51656-91-8

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane for 11.5h; Ambient temperature;100%
With sodium hydride In tetrahydrofuran at 0℃; for 0.666667h; Horner-Wadsworth-Emmons reaction;100%
Stage #1: cyclohexanedione monoethylene ketal With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h;
Stage #2: diethoxyphosphoryl-acetic acid ethyl ester In tetrahydrofuran; mineral oil at -20 - 20℃; for 3h;
100%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl P,P-bis(trimethylsilyl) phosphonoacetate
65868-40-8

ethyl P,P-bis(trimethylsilyl) phosphonoacetate

Conditions
ConditionsYield
at 100℃; for 168h; Inert atmosphere;100%
With potassium iodide In acetonitrile at 25 - 35℃; for 0.5h;
In chlorobenzene at 140℃; for 18h;
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Octanal
124-13-0

Octanal

ethyl (E)-2-decenate
7367-88-6

ethyl (E)-2-decenate

Conditions
ConditionsYield
With n-butyllithium In 1,2-dimethoxyethane; hexane 1.) 0 deg C, 10 min, 2.) 30 min;100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In diethyl ether at 0℃; for 0.0833333h;
Stage #2: Octanal In diethyl ether for 0.25h;
96%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In diethyl ether; mineral oil at 0℃;
Stage #2: Octanal In diethyl ether; mineral oil at 0℃;
96%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(E)-4,4-Dimethyl-7-(2-oxo-cyclohex-3-enyl)-hept-2-enal

(E)-4,4-Dimethyl-7-(2-oxo-cyclohex-3-enyl)-hept-2-enal

6-(6-ethoxycarbonyl-4,4-dimethylhex-5-enyl)cyclohex-2-enone
91200-48-5

6-(6-ethoxycarbonyl-4,4-dimethylhex-5-enyl)cyclohex-2-enone

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane for 1h; Ambient temperature;100%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(3S,10S,13S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta-[a]phenanthren-17-one
57711-44-1

(3S,10S,13S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta-[a]phenanthren-17-one

(E)-ethyl 3β-(tert-butyldimethylsiloxy)-5α-pregn-17-(20)-en-21-oate
115019-45-9

(E)-ethyl 3β-(tert-butyldimethylsiloxy)-5α-pregn-17-(20)-en-21-oate

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran; ethanol at 85℃; for 15h;100%
With sodium ethanolate In tetrahydrofuran; ethanol for 10h; Heating;98.6%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(E)-4-<(E)-1-methyl-3-(2,6,6-trimethyl-1-cyclohexenyl)-2-propenylidene>-2-cyclohexen-1-one
123718-34-3

(E)-4-<(E)-1-methyl-3-(2,6,6-trimethyl-1-cyclohexenyl)-2-propenylidene>-2-cyclohexen-1-one

ethyl (13E/Z)-10,20-methanoretinoate

ethyl (13E/Z)-10,20-methanoretinoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2.5h; Ambient temperature;100%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazole-3-carboxaldehyde
144148-22-1

7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazole-3-carboxaldehyde

ethyl (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenoate
144148-78-7

ethyl (E)-3-<7-(4-tert-butylbenzyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl>-2-propenoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Ambient temperature;100%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(5-Oxo-1-trityloxymethyl-pentyl)-carbamic acid methyl ester

(5-Oxo-1-trityloxymethyl-pentyl)-carbamic acid methyl ester

rac-(E)-ethyl 7-(methoxycarbonyl)amino-8-(trityloxy)-2-octenoate
157330-99-9

rac-(E)-ethyl 7-(methoxycarbonyl)amino-8-(trityloxy)-2-octenoate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 0.5h; Ambient temperature;100%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

(E)-ethyl 3-(3-nitrophenyl)acrylate
621-19-2

(E)-ethyl 3-(3-nitrophenyl)acrylate

Conditions
ConditionsYield
With water; barium dihydroxide In 1,4-dioxane at 70℃; for 0.416667h;100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester; 3-nitro-benzaldehyde With lithium chloride In acetonitrile at 0℃; for 0.0833333h; Horner-Wadsworth-Emmons reaction;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 20℃;
96%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: 3-nitro-benzaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h;
93%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3,4,5-trimethoxy-benzaldehyde
86-81-7

3,4,5-trimethoxy-benzaldehyde

ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate
1878-29-1, 30273-65-5, 31892-98-5

ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With lithium chloride In tetrahydrofuran at 20℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: 3,4,5-trimethoxy-benzaldehyde With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
100%
With potassium carbonate In water at 70℃; for 4h;90%
With potassium carbonate In water at 70℃; for 4h; Wittig Olefination; stereoselective reaction;90%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

benzaldehyde
100-52-7

benzaldehyde

ethyl cinnamate
4192-77-2

ethyl cinnamate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 1h;100%
With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 2h; Horner-Wadsworth-Emmons reaction; neat (no solvent); optical yield given as %de; stereoselective reaction;100%
With n-butyllithium In tetrahydrofuran; hexane 1.) 0 deg C, 10 min, 2.) 30 min;99%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

ethyl (E)-3-(3-chlorophenyl)prop-2-enoate
2373-88-8, 118315-76-7, 62174-98-5

ethyl (E)-3-(3-chlorophenyl)prop-2-enoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 23℃; for 1h;
Stage #2: m-Chlorobenzaldehyde In tetrahydrofuran for 1h;
100%
With sodium hydride In N,N-dimethyl-formamide at -60℃; Horner-Wadsworth-Emmons Olefination;95%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; for 4h; Glovebox;84%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

ethyl (E)-3-(3-methoxyphenyl)acrylate
33877-04-2, 24393-55-3

ethyl (E)-3-(3-methoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With lithium chloride In tetrahydrofuran at 20℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: 3-methoxy-benzaldehyde With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
100%
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h;100%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; for 4h; Glovebox;98%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

isovaleraldehyde
590-86-3

isovaleraldehyde

ethyl (E)-5-methylhex-2-enoate
34993-63-0

ethyl (E)-5-methylhex-2-enoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In 1,2-dimethoxyethane at 0℃; for 0.416667h;
Stage #2: isovaleraldehyde In 1,2-dimethoxyethane for 16h; Horner-Emmons homologation; Heating;
100%
With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 6h; Wadsworth-Honer-Emmons olefination;95%
With sodium hydride In tetrahydrofuran90%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

2,6-dimethylbenzaldehyde
1123-56-4

2,6-dimethylbenzaldehyde

ethyl (E)-3-(2,6-dimethylphenyl)-2-propenoate
527759-23-5

ethyl (E)-3-(2,6-dimethylphenyl)-2-propenoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 2,6-dimethylbenzaldehyde In tetrahydrofuran at 20℃; for 6h; Horner-Wadsworth-Emmons reaction;
100%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; for 4h; Glovebox;97%
With potassium tert-butylate Horner-Wadsworth-Emmons olefination;89%
With potassium tert-butylate In tetrahydrofuran Ambient temperature;
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

isobutyraldehyde
78-84-2

isobutyraldehyde

(E)-2-(Diethoxy-phosphoryl)-4-methyl-pent-2-enoic acid ethyl ester
173724-80-6

(E)-2-(Diethoxy-phosphoryl)-4-methyl-pent-2-enoic acid ethyl ester

Conditions
ConditionsYield
With piperidine; acetic acid In benzene for 48h; Heating;100%
With piperidine; acetic acid for 62h; Condensation; Knoevenagel condensation;80%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With triethylamine; titanium tetrachloride In dichloromethane at 0 - 5℃;
Stage #2: isobutyraldehyde In dichloromethane at 0 - 5℃; Horner-Wadsworth-Emmos reaction;
3,4-dibenzyloxybenzaldehyde
5447-02-9

3,4-dibenzyloxybenzaldehyde

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3-(3,4-bis-benzyloxy-phenyl)-acrylic acid ethyl ester
203571-40-8

3-(3,4-bis-benzyloxy-phenyl)-acrylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran
Stage #2: 3,4-dibenzyloxybenzaldehyde In tetrahydrofuran for 0.166667h; Further stages.;
100%
With sodium hydride In 1,2-dimethoxyethane for 0.333333h;99.5%
With sodium In ethanol Ambient temperature;76%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(S)-3-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-thiazol-4-yl]-butyraldehyde
185996-42-3

(S)-3-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-thiazol-4-yl]-butyraldehyde

(E)-(S)-5-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-thiazol-4-yl]-hex-2-enoic acid ethyl ester
185996-43-4

(E)-(S)-5-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-thiazol-4-yl]-hex-2-enoic acid ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride In acetonitrile for 0.25h; Ambient temperature;100%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(1R,5R,6R)-2-[6-(tert-butyldimethylsilanyloxymethyl)-5-isopropyl-2-methylcyclohex-2-enyl]acetaldehyde
198336-00-4

(1R,5R,6R)-2-[6-(tert-butyldimethylsilanyloxymethyl)-5-isopropyl-2-methylcyclohex-2-enyl]acetaldehyde

(E)-4-[(1R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enyl]-but-2-enoic acid ethyl ester
198336-01-5

(E)-4-[(1R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enyl]-but-2-enoic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 25℃;100%
With sodium hydride 1.) THF, 25 deg C, 30 min, 2.) THF, from 0 to 25 deg C, 5 h; Yield given. Multistep reaction;
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

(1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester
181646-38-8

(1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester

ethyl (2E)-5-(tert-butoxycarbonylamino)-5-methylhex-2-enoate
181646-40-2

ethyl (2E)-5-(tert-butoxycarbonylamino)-5-methylhex-2-enoate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate In toluene at 60℃; for 0.5h; Wittig-Horner reaction;
Stage #2: (1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester In toluene at 60℃; for 0.166667h; Wittig-Horner reaction;
100%
With potassium tert-butylate 1.) THF, RT, 40 min, 2.) THF, RT, 75 min; Yield given. Multistep reaction;
With potassium tert-butylate; sodium hydrogencarbonate In tetrahydrofuran; n-heptane

867-13-0Relevant articles and documents

Reimann,Voss

, p. 2,8 (1977)

One-pot synthesis and antimicrobial of novel 6-ethoxy-6-oxido-3-oxo(thioxo) (imino)-5-substituted-2,7-dihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes

Ali, Tarik E.,Assiri, Mohammed A.

, p. 965 - 969 (2021)

A series of novel 6-ethoxy-6-oxido-3-oxo(thioxo)(imino)-5-substituted-2,7-dihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes 2a-f was synthesized and characterized by IR and NMR (1H, 13C, and 31P) spectroscopic analysis. The methodology developed was one-pot three-component reaction of ethyl bromoacetate, triethyl phosphite and carbo(thio)(amino)hydrazides. The synthesized compounds were screened for their antimicrobial activities. 6-Ethoxy-6-oxido-3-oxo(thioxo)-5-phenyl-2,5,7-trihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes (2c,d) exhibited significantly higher antimicrobial effects against the tested bacterial and fungal strains compared to other compounds and standard drug.

Enantioselective Michael addition to vinyl phosphonatesviahydrogen bond-enhanced halogen bond catalysis

Erkman, Kristin,J?rving, Ivar,Kaasik, Mikk,Kanger, T?nis,Mart?nova, Jevgenija,Metsala, Andrus

, p. 7561 - 7568 (2021/06/09)

An asymmetric Michael addition of malononitrile to vinyl phosphonates was accomplished by hydrogen bond-enhanced bifunctional halogen bond (XB) catalysis. NMR titration experiments were used to demonstrate that halogen bonding, with the support of hydrogen-bonding, played a key role in the activation of the Michael acceptors through the phosphonate group. This is the first example of the use of XBs for the activation of organophosphorus compounds in synthesis. In addition, the iodo-perfluorophenyl group proved to be a better directing unit than different iodo- and nitro-substituted phenyl groups. The developed approach afforded products with up to excellent yields and diastereoselectivities and up to good enantioselectivities.

Alkyl phosphonate preparing method

-

Paragraph 0040; 0041; 0042; 0043; 0044-0067; 0096; 0097, (2017/10/07)

The invention provides an alkyl phosphonate preparing method. The method comprises: performing an Arbuzov reaction on compound A and compound B in a continuous reaction apparatus, and continuously discharging the product obtained from the reaction from the continuous reaction apparatus during the reaction procedure, to obtain alkyl phosphonate. The reaction temperature in the reaction procedure is T1; either of compound A and compound B having a lower boiling point has a boiling point at a standard atmosphere pressure to be T2; T1 is higher than T2 by 10-40 DEG C; and the reaction pressure in the reaction procedure is 0.5-2.0 MPa. The preparing method in the invention may use halohydrocarbon having large steric hindrance and lower polarizability of carbon-halogen bond as compound A, thereby effectively expanding a selection range of substrate, and correspondingly expanding the types of alkyl phosphonate prepared by using the Arbuzov reaction.

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