867021-83-8 Usage
Description
Colivelin is a potent synthetic peptide activator of STAT3 that exhibits neuroprotective activity. It has been shown to protect mouse primary cortical neurons from cell death induced by amyloid β and improve working memory through increased STAT3 phosphorylation. Colivelin also rescues deficits in spatial working memory in a mouse model of Alzheimer's disease and improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).
Uses
Used in Pharmaceutical Industry:
Colivelin is used as a neuroprotective agent for the treatment of Alzheimer's Disease (AD). It activates the JAK2/STAT3 pathway, which is implicated in the pathogenesis of AD, and offers neuroprotective effects against the disease.
Used in Neurodegenerative Disease Research:
Colivelin is used as a therapeutic agent in mouse models of neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS), to study its potential benefits in improving cognitive function, motor performance, and overall survival.
Check Digit Verification of cas no
The CAS Registry Mumber 867021-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,7,0,2 and 1 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 867021-83:
(8*8)+(7*6)+(6*7)+(5*0)+(4*2)+(3*1)+(2*8)+(1*3)=178
178 % 10 = 8
So 867021-83-8 is a valid CAS Registry Number.
