868241-48-9

Basic information

• Product Name: 2,2-Difluoropropylamine hydrochloride
• Synonyms: 1-Amino-2,2-difluoropropane hydrochloride;1-Propanamine, 2,2-difluoro-, hydrochloride;2,2-DIFLUOROPROPAN-1-AMINE HCL;2,2-Difluoro-1-propanamine hydrochloride
• CAS NO: 868241-48-9
• Molecular Formula: C₃H₇F₂N*ClH
• Molecular Weight: 132
• Mol File: 868241-48-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 235-239 °C
• Boiling Point: 77.9°C at 760 mmHg
• Appearance: /
• Vapor Pressure: 94.9mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,2-Difluoropropylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Difluoropropylamine hydrochloride(868241-48-9)
• EPA Substance Registry System: 2,2-Difluoropropylamine hydrochloride(868241-48-9)

Safety Data

• Hazardous Substances Data: 868241-48-9(Hazardous Substances Data)

Usage

General Description

2,2-Difluoropropylamine hydrochloride is a chemical compound with the molecular formula C3H8F2NCl. It is a derivative of propanamine, containing two fluorine atoms and a hydrochloride salt. 2,2-Difluoropropylamine hydrochloride is commonly used in pharmaceutical and chemical research as a building block in the synthesis of various organic compounds, particularly in the development of new drugs. It plays a crucial role in the creation of fluorinated organic molecules, which have unique properties and are utilized in a wide range of applications. Its structure and properties make it a valuable tool for scientists and researchers in the field of organic chemistry.

InChI:InChI=1/C3H7F2N.ClH/c1-3(4,5)2-6;/h2,6H2,1H3;1H

Upstream product

• 1017241-19-8 2-(2,2-difluoropropyl)isoindoline-1,3-dione 

Downstream Products

• 1149341-28-5 1-(2-chlorophenyl)-5-(4-chlorophenyl)-N-(2,2-difluoropropyl)-4-vinyl-1Hpyrazole-3-carboxamide 
• 1428243-32-6 (3S,4R)-N-(2,2-difluoropropyl)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxamide 
• 1578244-45-7 N₈-(2,2-difluoropropyl)-N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine 

Relevant articles and documents

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)- 6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity

We report the design, synthesis, and structure-activity relationships of novel bicyclic lactam-based cannabinoid type 1 (CB1) receptor antagonists. Members of these series are potent, selective antagonists in in vitro/in vivo efficacy models of CB1 antagonism and exhibit robust oral activity in rodent models of food intake. These efforts led to the identification of 19d, which has been advanced to human clinical trials for weight management.