868656-97-7

Basic information

• Product Name: 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER
• Synonyms: 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER;6-Bromo-1H-indole-3-carboxylic acid methyl ester;6-Bromo-1H-indole-3-Carbocylic acid methyl ester
• CAS NO: 868656-97-7
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08
• EINECS: 200-589-5
• Mol File: 868656-97-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 386.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.629±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.49±0.30(Predicted)
• CAS DataBase Reference: 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER(868656-97-7)
• EPA Substance Registry System: 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER(868656-97-7)

Safety Data

• Hazardous Substances Data: 868656-97-7(Hazardous Substances Data)

Usage

General Description

1H-Indole-3-carboxylic acid, 6-bromo-, methyl ester is a chemical compound that belongs to the class of indole derivatives. It is a methyl ester of 6-bromo-1H-indole-3-carboxylic acid, which is commonly used in the synthesis of pharmaceuticals and agrochemicals. 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-,METHYL ESTER has potential applications in the field of medicinal chemistry and drug discovery, as it can serve as a precursor for the synthesis of bioactive molecules with diverse biological activities. It is important to handle this chemical with care and follow proper safety protocols when working with it in a laboratory setting.

Upstream product

• 585-79-5 m-nitrobromobenzene 
• 24171-78-6 m-bromophenylhydroxylamine 
• 922-67-8 propynoic acid methyl ester 
• 79878-02-7 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethan-1-one 
• 67-56-1 methanol 
• 17826-04-9 6-bromo-1H-indole-3-carbaldehyde 
• 52415-29-9 6-bromo-1H-indole 
• 101774-27-0 6-bromo-1H-indole-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 771-50-6 1H-indole-3-carboxylic acid 

Downstream Products

• 1093631-89-0 methyl 6-[6-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-3-pyridinyl]-1H-indole-3-carboxylate 
• 1093631-54-9 6-[6-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-3-pyridinyl]-1H-indole-3-carboxylic acid 
• 1103500-20-4 TERN-101 
• 1103500-82-8 6-{4-[5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-ylmethoxy]piperidin-1-yl}-1-methyl-1H-indole-3-carboxylic acid methyl ester 

Relevant articles and documents

REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS

The present disclosure provides compounds of Formula IA and Formula IB and their pharmaceutical compositions as selective agonists of REV-ERB-α: where R1, R2, R3, R4, R5, RX1, RX2, nA, nB, X, Y, and Z are described herein. The compounds are useful in various methods and uses, such as in the treatment of diseases including hyperglycemia, dyslipidemia, atherosclerosis, and autoimmune and inflammatory disorders or diseases, and as cancer therapeutics, such as for the treatment of glioblastoma, hepatocellular carcinoma, and colorectal cancer, and for immune-oncology purposes.

A general and scalable synthesis of polysubstituted indoles

A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported. The protocol is based on the [3,3]-sigmatropic rearrangement of N-oxyenamines generated by the DABCO-catalyzed reaction of N-arylhydroxylamines and conjugated terminal alkynes, and delivers indoles endowed with a wide array of substitution patterns and topologies.

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.