86873-60-1

Basic information

• Product Name: 5-Chloropyridine-2-carboxylic acid
• Synonyms: 5-CHLORO-2-PYRIDINECARBOXYLIC ACID;5-CHLORO-2-PICOLINIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID;5-CHLOROPICOLINIC ACID;5-Chloropyridine-2-carboxylicacid98%;5-CHLORO-2-PYDRIDINECARBOXYLIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID 97%;5-CHLORO-2-PICOLINIC ACID (5-CHLORO-2-PYRIDINECARBOXYLIC ACID)
• CAS NO: 86873-60-1
• Molecular Formula: C₆H₄ClNO₂
• Molecular Weight: 157.55
• Product Categories: pharmacetical;Pyridines
• Mol File: 86873-60-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 166-171℃
• Boiling Point: 310.3 °C at 760 mmHg
• Flash Point: 141.5 °C
• Appearance: /
• Density: 1.47 g/cm³
• Vapor Pressure: 0.00026mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 5-Chloropyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloropyridine-2-carboxylic acid(86873-60-1)
• EPA Substance Registry System: 5-Chloropyridine-2-carboxylic acid(86873-60-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-40-22
• Safety Statements: 22-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 86873-60-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystal powder

Uses

5-Chloropicolinic Acid is an inhibitor of dopamine β-hydroxylase and has antihypertensive activity.

InChI:InChI=1/C6H4ClNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)

Upstream product

• 2138-22-9 4-chloro-1,2-benzenediol 
• 223445-06-5 5-Chloro-2-vinyl-pyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 124-38-9 carbon dioxide 
• 1072-98-6 5-chloro-2-pyridylamine 
• 89809-64-3 2-cyano-5-chloropyridine 
• 16110-09-1 2,5 dichloropyridine 
• 151-21-3 sodium dodecyl-sulfate 
• 109-89-7 diethylamine 
• 1066-54-2 trimethylsilylacetylene 
• 132308-15-7 4-(5-chloro-2-pyridyl)-2-methyl-3-butyn-2-ol 
• 858844-85-6 1,3-bis(6-methylpyridin-3-yl)urea 
• 70788-54-4 2,3,4-trichloro-6-(trichloromethyl)pyridine 
• 1199-48-0 4,5-dichloro-2-(trichloromethyl)pyridine 

Downstream Products

• 132308-19-1 methyl 5-chloropyridine-2-carboxylate 
• 128072-93-5 ethyl 5-chloropyridine-2-carboxylate 
• 748183-90-6 5-Chloropyridine-2-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide 
• 342601-76-7 5-chloro-N-methoxy-N-methylpicolinamide 
• 1235471-52-9 5-chloro-N-({1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methyl)-2-pyridinecarboxamide 
• 1057855-29-4 N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide 
• 1286182-11-3 N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride 
• 1600508-64-2 N-(3-((5S,6R)-8-amino-5-fluoro-6-methyl-4,4-dioxido-4-thia-7-azaspiro[2.5]oct-7-en-6-yl)-4-fluorophenyl)-5-chloropicolinamide 
• 1600507-91-2 N-(3-((6S,7R)-9-amino-6-fluoro-7-methyl-5,5-dioxido-5-thia-8-azaspiro[3.5]non-8-en-7-yl)-4-fluorophenyl)-5-chloro-2-pyridinecarboxamide 
• 1200493-76-0 (S)-N-(3-(2-amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide 
• 145835-01-4 5-chloropicolinohydrazide 

Relevant articles and documents

Betrixaban structural analogue as well as preparation method and application thereof

The invention provides a novel compound for preparation of drugs for treating venous thrombosis diseases, and particularly relates to a betrixaban structural analogue with a formula (I) shown in the following description or a pharmaceutically acceptable salt thereof, as well as a preparation method and application of the betrixaban structural analogue.

HYDRAZONE COMPOUNDS AND THEIR USE

The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.

AMIDE DERIVATIVES

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