868850-06-0

Basic information

• Product Name: 5-{4-[(3-fluorobenzyl)oxy]phenyl}pentanoic acid
• CAS NO: 868850-06-0
• Molecular Weight: 302.345
• Mol File: 868850-06-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{4-[(3-fluorobenzyl)oxy]phenyl}pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{4-[(3-fluorobenzyl)oxy]phenyl}pentanoic acid(868850-06-0)
• EPA Substance Registry System: 5-{4-[(3-fluorobenzyl)oxy]phenyl}pentanoic acid(868850-06-0)

Safety Data

• Hazardous Substances Data: 868850-06-0(Hazardous Substances Data)

Upstream product

• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 154044-13-0 ethyl 5-(4-(hydroxyl)phenyl)pentanoate 

Relevant articles and documents

Discovery of N-(3-{4-[(3-fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4- ylacetamide as a potent and selective reverse NCX inhibitor

In the setting of heart failure and myocardial ischemia-reperfusion, the sodium-calcium exchanger (NCX) can lead to calcium overload, which is responsible for contractile dysfunction and arrhythmia. NCX is an attractive target for treatment in heart failure and myocardial ischemia-reperfusion. We have designed and synthesized a series of benzyloxyphenyl derivatives based on compound 3. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward modes of NCX. We have discovered a novel potent and selective reverse NCX inhibitor (12) with an IC50 value of 0.085 μM against reverse NCX.