869304-54-1Relevant articles and documents
Synthesis and biological evaluation of new tetrahydro-β-carbolines as inhibitors of the mitotic kinesin Eg5
Sunder-Plassmann, Nils,Sarli, Vasiliki,Gartner, Michael,Utz, Mathias,Seiler, Jeanette,Huemmer, Stefan,Mayer, Thomas U.,Surrey, Thomas,Giannis, Athanassios
, p. 6094 - 6111 (2007/10/03)
The mitotic kinesin Eg5 (or KSP) is a crucial player in the development and function of the mitotic spindle. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering with other microtubule-dependent processes. Therefore, it