869365-97-9Relevant articles and documents
Small molecule with Aurora kinase degradation activity, preparation method and application thereof
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Paragraph 0065; 0067, (2020/12/30)
The invention discloses a small molecule with Aurora kinase degradation activity, a preparation method and application thereof. According to the invention, 12 Aurora-A protein degradation agents basedon a PROTAC technology are obtained by using three E3 u
Bioorthogonal imaging of Aurora Kinase A in live cells
Yang, Katherine S.,Budin, Ghyslain,Reiner, Thomas,Vinegoni, Claudio,Weissleder, Ralph
, p. 6598 - 6603 (2012/09/22)
In living color: Aurora kinase A (AKA) was imaged in live cells using a bioorthogonal two-step reaction with a small molecule AKA inhibitor (see scheme) and a fluorescent reporter. The fluorescent molecule was localized to spindle poles and microtubules d
Compounds and methods for inhibiting mitotic progression
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Page/Page column 141, (2008/06/13)
This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat