86938-17-2Relevant articles and documents
PRODUCTION PROCESSES OF S- AND O-DIACYLATED GAMMA-GLUTAMYL-CYSTEAMINE PRODRUGS
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, (2020/08/28)
Methods are provided for the synthesis of a compound of formula (X). R2 is selected from -H, -C1-C4-alkyl,-C2-C4-alkenyl and C1-C4-aryl; R3 is selected from -C(O)H and
Synthesis of diacylated γ3-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine
Frost, Lisa,Suryadevara, Pratap,Cannell, Stephanie J.,Groundwater, Paul W.,Hambleton, Paul A.,Anderson, Rosaleen J.
, p. 206 - 215 (2016/01/26)
To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ3-glutamyl-cysteamine (4) were synthesized for evaluation. Esterification of the thiol conferred oxidative stabilit
GLUTAMATE DERIVATIVES OR SALTS THEREOF
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Paragraph 0109, (2013/03/26)
Compounds having an excellent CaSR agonist activity are in demand. The invention provides glutamate derivatives or salts thereof, pharmaceutical compositions comprising the glutamate derivatives, preventive or therapeutic agents for diarrhea, hyperparathyroidism or peptic ulcer.